Journal
BIOMACROMOLECULES
Volume 23, Issue 6, Pages 2329-2341Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.biomac.2c00077
Keywords
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Funding
- National Natural Science Foundation of China [21835005, U1862109]
- Science and Technology Development Plan Project of Suzhou [SNG2021011]
- Livelihood Technology Project of Suzhou [SKJY2021042]
- Collaborative Innovation Center of Suzhou Nano Science and Technology
- Priority Academic Program Development of Jiangsu Higher Education Institutions
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This study developed a coating on biomedical device surfaces that releases nitric oxide (NO) gas, effectively preventing bacterial infections and biofilm formation. The coating showed long-lasting antimicrobial activity and reduced adsorption of proteins and bacteria. The released NO also inhibited wound infection and inflammation.
Infections caused by bacteria and biofilms on the surfaces of biomedical devices and implants pose serious threats to public health. Herein, a nitric oxide (NO) gas-releasing quaternary ammonium-type ionic liquid (IL)-based coating on polydimethylsiloxane (PDMS), PDIL-NO, with effective and long-acting antibacterial and antifouling properties was prepared. N-(2((2, 3-Dimethylbut-3-enoyl)oxy)ethyl)-N, N-dimethyloctan-1-aminium bromide (IL-Br), and 2-methyl-2-propenoic acid 2-(2methoxyethoxy) ethyl ester were covalently grafted onto the surfaces of PDMS by a thiol-ene click chemical reaction, followed by incorporation of L-proline anions (Pro-) through anion exchange with Br- to adsorb NO gas. The prepared PDIL-NO showed a prolonged NO-releasing time (>1440 min) and a relatively high concentration (88 mu M). Additionally, PDIL-NO possessed good and long-term antimicrobial activity, and could effectively reduce the adsorption of bovine serum albumin and adhesion of bacteria, as well as inhibit wound infection and reduce inflammation in vivo due to the synergetic effect of IL and the released NO. This study may provide a new approach to combat bacterial infections associated with biomedical devices and implants.
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