Journal
BIOMACROMOLECULES
Volume 23, Issue 6, Pages 2485-2495Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.biomac.2c00232
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Funding
- French National Research Agency [ANR-10-INBS-04]
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In this study, the (Z) and (E)-isomers of a tetraphenylethylene-based chromophore were separated and functionalized, resulting in water-soluble polymer nanoparticles. Comparisons with previous studies demonstrate that the later functionalization can effectively control the self-assembly of the nanoparticles and improve their biocompatibility towards the imaged organism.
The (Z) and (E)-isomers of an extended tetraphenylethylene-based chromophore with optimized two-photon-induced luminescence properties are separated and functionalized with water-solubilizing pendant polymer groups, promoting their self-assembly in physiological media in the form of small, colloidal stable organic nanoparticles. The two resulting fluorescent suspensions are then evaluated as potential two-photon luminescent contrast agents for intravital epifluorescence and two-photon fluorescence microscopy. Comparisons with previously reported works involving similar fluorophores devoid of polymer side chains illustrate the benefits of later functionalization regarding the control of the self-assembly of the nano-objects and ultimately their biocompatibility toward the imaged organism.
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