Journal
BIOLOGICAL PSYCHOLOGY
Volume 169, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.biopsycho.2022.108266
Keywords
Interoception; Active inference; Predictive coding; Homeostasis; Allostasis
Funding
- European Union [945539]
- European Research Council [820213]
- Dr. Mortimer and Theresa Sackler Foundation
- BBRSC [BB/P022197/1]
- European Research Council (ERC) [820213] Funding Source: European Research Council (ERC)
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This article uses the framework of active inference to simulate and study interoceptive control and its dysfunctions. Interoceptive control aims to minimize the discrepancy between expected and actual interoceptive sensations through different forms of control. The analysis of generative models within active inference provides predictions for physiological and brain signals, supporting empirical research.
The adaptive regulation of bodily and interoceptive parameters, such as body temperature, thirst and hunger is a central problem for any biological organism. Here, we present a series of simulations using the framework of active inference to formally characterize interoceptive control and some of its dysfunctions. We start from the premise that the goal of interoceptive control is to minimize a discrepancy between expected and actual interoceptive sensations (i.e., a prediction error or free energy). Importantly, living organisms can achieve this goal by using various forms of interoceptive control: homeostatic, allostatic and goal-directed. We provide a computationally-guided analysis of these different forms of interoceptive control, by showing that they correspond to distinct generative models within Active inference. We discuss how these generative models can support empirical research through enabling fine-grained predictions about physiological and brain signals that may accompany both adaptive and maladaptive interoceptive control.
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