Cortical Microcircuits Mired by Chronic Stress

Article Neurosciences

Chronic Stress Induces Coordinated Cortical Microcircuit Cell-Type Transcriptomic Changes Consistent With Altered Information Processing

Dwight F. Newton et al.

Summary: This study investigated the transcriptomic effects of chronic stress on microcircuit cell types in the medial prefrontal cortex of mice. The results showed changes in behavior, dysregulation of gene expression, and reorganization of synaptic connections across different cell types, suggesting a shift in the regulation of cortical excitation-inhibition balance.

BIOLOGICAL PSYCHIATRY (2022)

Add to Collection

Article Neurosciences

Transcriptomic organization of the human brain in post-traumatic stress disorder

Matthew J. Girgenti et al.

Summary: This study provides comprehensive insights into the molecular pathology of post-traumatic stress disorder (PTSD) through transcriptome analysis of postmortem brains, revealing extensive remodeling of gene expression networks and identifying genetic susceptibility factors, as well as marked transcriptional sexual dimorphism. Additionally, comparison with major depressive disorder cohorts shows significant differences between the molecular profiles of individuals with PTSD and major depressive disorder despite their high comorbidity, supporting the notion that PTSD has distinct molecular determinants.

NATURE NEUROSCIENCE (2021)

Add to Collection

Review Neurosciences