Journal
BIOINFORMATICS
Volume 38, Issue 10, Pages 2963-2964Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btac204
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Funding
- French government under Agence Nationale de la Recherche as part of the 'Investissements d'avenir' program [ANR-19-P3IA-0001]
- European Union [826121]
- Fondation ARC
- Innovative Medicines Initiative 2 Joint Undertaking [821558]
- Ministry of Education and Science of the Republic of Kazakhstan [AP09058660]
- Luxembourg National Research Fund [C17/BM/11664971/DEMICS]
- CRP NU [021220CRP222]
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BIODICA is an integrated computational environment for analyzing bulk and single-cell molecular profiles, allowing non-experts to perform ICA-based omics data analysis and communicate with biology experts through interactive graphical user interface.
A Summary: We developed BIODICA, an integrated computational environment for application of independent component analysis (ICA) to bulk and single-cell molecular profiles, interpretation of the results in terms of biological functions and correlation with metadata. The computational core is the novel Python package stabilized-ica which provides interface to several ICA algorithms, a stabilization procedure, meta-analysis and component interpretation tools. BIODICA is equipped with a user-friendly graphical user interface, allowing non-experienced users to perform the ICA-based omics data analysis. The results are provided in interactive ways, thus facilitating communication with biology experts.
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