Journal
BIOINFORMATICS
Volume 38, Issue 9, Pages 2657-2658Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btac132
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Funding
- Generalitat Valenciana through PROMETEO [PROMETEO 2016/093]
- Spanish MICINN [PID2020-119537RB-I00]
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This article introduces the MultiBaC R package, a tool for batch effect removal in multi-omics and hidden batch effect scenarios. It includes various graphical outputs for model validation and assessment of batch effect correction.
Motivation: Batch effects in omics datasets are usually a source of technical noise that masks the biological signal and hampers data analysis. Batch effect removal has been widely addressed for individual omics technologies. However, multi-omic datasets may combine data obtained in different batches where omics type and batch are often confounded. Moreover, systematic biases may be introduced without notice during data acquisition, which creates a hidden batch effect. Current methods fail to address batch effect correction in these cases. Results: In this article, we introduce the MultiBaC R package, a tool for batch effect removal in multi-omics and hidden batch effect scenarios. The package includes a diversity of graphical outputs for model validation and assessment of the batch effect correction.
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