Resveratrol oligomers from roots of Ampelocissus martini Planch

Phytochemical investigation of roots of Ampelocissus martini Planch. (Vitaceae family) led to the isolation of five resveratrol oligomers comprising (-)-ampelopsin F (1), (+)-hopeaphenol (2), (-)-alpha-viniferin (3), (-)-wilsonol A (4) and (-)-stenophyllol B (5). The structure elucidation was performed using their spectroscopic data as well as comparison with those of literature data. All the isolated compounds were submitted to anti-HIV-1 activities employing the syncytium inhibition assay, using the (Delta Tat/Rev)-MC99 virus and 1A2 cell line system, and the reverse transcriptase (RT) assay. The results revealed that the enzymatic inhibition of tested compounds except compound 1 exhibited the potential inhibition in anti-HIV 1-RT assay with IC50 in the range of 1.68-5.85 mu M better than the positive control, navirapin (IC50 at 7.77 mu M). Based on the results, their activities displayed the RT enzymatic inhibition better than the positive control. In addition, the chemical isolation of A. martini was studied for the first time herein. All known secondary metabolites except compound 2 were firstly reported from Ampelocissus genus. Furthermore, the chemotaxonomic significance of the isolates was discussed.

Automated summary

Phytochemical investigation of the roots of Ampelocissus martini Planch. led to the isolation of five resveratrol oligomers. The isolated compounds showed better RT enzymatic inhibition than the positive control in anti-HIV 1-RT assay. This study also reported the chemical isolation of A. martini for the first time and discussed the chemotaxonomic significance of the isolates.