4.7 Article

Myricetin inhibits interferon-γ-induced PD-L1 and IDO1 expression in lung cancer cells

Related references

Note: Only part of the references are listed.
Review Chemistry, Multidisciplinary

Small molecule inhibitors targeting the PD-1/PD-L1 signaling pathway

Qian Wu et al.

Summary: PD-1/PD-L1 signaling pathway is a target for anticancer drugs, and the development of small molecule inhibitors provides a new avenue for tumor immunotherapy.

ACTA PHARMACOLOGICA SINICA (2021)

Article Biochemistry & Molecular Biology

The anti-STAT1 polyphenol myricetin inhibits M1 microglia activation and counteracts neuronal death

Diana Boriero et al.

Summary: The study highlighted the potential role of MYR in inhibiting M1 microglia activation and preventing neuroinflammation by targeting the STAT1 signaling pathway.

FEBS JOURNAL (2021)

Article Immunology

Genome-wide Screens Identify Lineage- and Tumor-Specific Genes Modulating MHC-I- and MHC-II-Restricted Immunosurveillance of Human Lymphomas

Devin Dersh et al.

Summary: Genome-wide screening in diffuse large B cell lymphomas identified genes that modulate MHC-I cell surface expression in multiple pathways. These genes represent potential targets for manipulating MHC-I immunosurveillance in cancers and other diseases. Pharmacological inhibition of negative regulators of antigen presentation enhanced MHC-I presentation in DLBCL.

IMMUNITY (2021)

Review Medicine, Research & Experimental

Myricetin: A review of the most recent research

Xiaominting Song et al.

Summary: This review comprehensively summarizes the biological functions of MYR and its therapeutic effects on various diseases, discusses the potential molecular mechanisms, and suggests that MYR may serve as an adjuvant treatment for multiple diseases.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Medicine, Research & Experimental

Advance investigation on synthetic small-molecule inhibitors targeting PD-1/PD-L1 signaling pathway

Annoor Awadasseid et al.

Summary: Immune checkpoint blockade targeting the PD-1/PD-L1 signaling pathway has shown promising results in cancer therapy by degrading anti-tumor immune response. The axis PD-1/PD-L1 is crucial for immune escape of cancer and has a significant impact on cancer treatment. Further research on PD-1 and PD-L1 function aims to enhance cancer therapy.

LIFE SCIENCES (2021)

Review Oncology

Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors in clinical trials for cancer immunotherapy

Kai Tang et al.

Summary: IDO1 is an important heme enzyme involved in cancer immune escape, associated with poor prognosis in various cancers, and currently undergoing clinical trials with multiple drugs. The development of IDO1 degraders using PROTAC technology presents a novel therapeutic approach.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

Article Oncology

Apatinib triggers autophagic and apoptotic cell death via VEGFR2/STAT3/PD-L1 and ROS/Nrf2/p62 signaling in lung cancer

Chunfeng Xie et al.

Summary: Apatinib inhibits cell proliferation and promotes apoptosis in non-small cell lung cancer cells through modulation of various signaling pathways. It suppresses malignant and stem-like features of cancer cells and induces autophagy and apoptotic cell death. Additionally, apatinib shows promising effects in inhibiting tumor growth in vivo.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

Article Biochemistry & Molecular Biology

Activated T cell-derived exosomal PD-1 attenuates PD-L1-induced immune dysfunction in triple-negative breast cancer

Yufan Qiu et al.

Summary: The study reveals that PD-1 can be secreted in an exosomal form by activated T cells and interact remotely with PD-L1. This interaction can attenuate the suppression of tumor-specific cytotoxic T cell activity by PD-L1, restoring tumor surveillance.

ONCOGENE (2021)

Article Oncology

Regulation of CD47 expression by interferon-gamma in cancer cells

Zi-Han Ye et al.

Summary: IFN-gamma up-regulates CD47 expression in cancer cells, leading to decreased phagocytosis by macrophages, which can be inhibited by ruxolitinib and silencing of specific genes. This discovery provides insights into potential cancer immunotherapy targeting CD47.

TRANSLATIONAL ONCOLOGY (2021)

Review Oncology

Extracellular and nuclear PD-L1 in modulating cancer immunotherapy

Wenjun Xiong et al.

Summary: Understanding the regulatory mechanisms of the PD-1/PD-L1 axis is crucial for overcoming obstacles of PD-1/PD-L1 blockade. The roles of extracellular and nuclear PD-L1 play a critical role in regulating cancer immune evasion and immunotherapy.

TRENDS IN CANCER (2021)

Article Biochemical Research Methods

Tumor organoid-T-cell coculture systems

Chiara M. Cattaneo et al.

NATURE PROTOCOLS (2020)

Article Integrative & Complementary Medicine

A study on the mechanism of bruceine D in the treatment of non-small cell lung cancer H1299 cells

Xiao-Yun Shen et al.

WORLD JOURNAL OF TRADITIONAL CHINESE MEDICINE (2020)

Article Biochemistry & Molecular Biology

Mitomycin C enhanced the efficacy of PD-L1 blockade in non-small cell lung cancer

Min Luo et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Review Integrative & Complementary Medicine

Myricetin bioactive effects: moving from preclinical evidence to potential clinical applications

Yasaman Taheri et al.

BMC COMPLEMENTARY MEDICINE AND THERAPIES (2020)

Review Oncology

Exosomal PD-L1: Roles in Tumor Progression and Immunotherapy

Samantha M. Morrissey et al.

TRENDS IN CANCER (2020)

Article Cell Biology

Interferon γ and Its Important Roles in Promoting and Inhibiting Spontaneous and Therapeutic Cancer Immunity

Elise Alspach et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2019)

Article Oncology

Met inhibition revokes IFNγ-induction of PD-1 ligands in MET-amplified tumours

Valentina Martin et al.

BRITISH JOURNAL OF CANCER (2019)

Article Biochemistry & Molecular Biology

Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory

Mauro Poggio et al.

Article Oncology

Antitumor activity of dual blockade of PD-L1 and MEK in NSCLC patients derived three-dimensional spheroid cultures

Carminia Maria Della Corte et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

Article Oncology

Mechanisms regulating PD-L1 expression on tumor and immune cells

Shuming Chen et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)

Review Medicine, Research & Experimental

Anti-tumor effects and associated molecular mechanisms of myricetin

Min Jiang et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

Review Immunology

IDO1 in cancer: a Gemini of immune checkpoints

Lijie Zhai et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2018)

Article Multidisciplinary Sciences

CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity

Marian L. Burr et al.

NATURE (2017)

Article Nanoscience & Nanotechnology

In vitro and in vivo evaluation of functionalized chitosan-Pluronic micelles loaded with myricetin on glioblastoma cancer

Gang Wang et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2016)

Review Medicine, General & Internal

Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway

Vassiliki A. Boussiotis

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Review Nutrition & Dietetics

Myricetin: A Dietary Molecule with Diverse Biological Activities

Deepak Kumar Semwal et al.

NUTRIENTS (2016)

Article Cell Biology

Myricetin inhibits proliferation and induces apoptosis and cell cycle arrest in gastric cancer cells

Jianfang Feng et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2015)

Article Biochemical Research Methods

Efficient conversion of myricetin from Ampelopsis grossedentata extracts and its purification by MIP-SPE

Shian Zhong et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2014)

Review Neurosciences

Kynurenines in CNS disease: regulation by inflammatory cytokines

Brian M. Campbell et al.

FRONTIERS IN NEUROSCIENCE (2014)

Review Virology

HIV-1 Nef and T-cell activation: a history of contradictions

Tristan J. Markle et al.

FUTURE VIROLOGY (2013)

Review Immunology

Oncology Meets Immunology: The Cancer-Immunity Cycle

Daniel S. Chen et al.

IMMUNITY (2013)

Review Oncology

The blockade of immune checkpoints in cancer immunotherapy

Drew M. Pardoll

NATURE REVIEWS CANCER (2012)

Article Oncology

The Two Faces of Interferon-γ in Cancer

M. Raza Zaidi et al.

CLINICAL CANCER RESEARCH (2011)

Editorial Material Immunology

IDO: more than an enzyme

WanJun Chen

NATURE IMMUNOLOGY (2011)

Article Multidisciplinary Sciences

NLR family member NLRC5 is a transcriptional regulator of MHC class I genes

Torsten B. Meissner et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Oncology

Myricetin directly targets JAK1 to inhibit cell transformation

Takuma Kumamoto et al.

CANCER LETTERS (2009)

Article Agriculture, Multidisciplinary

Myricetin Suppresses Invasion and Migration of Human Lung Adenocarcinoma A549 Cells: Possible Mediation by Blocking the ERK Signaling Pathway

Yuan-Wei Shih et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2009)

Article Multidisciplinary Sciences

Unphosphorylated STAT1 prolongs the expression of interferon-induced immune regulatory genes

HyeonJoo Cheon et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)