Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 597, Issue -, Pages 140-146Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2022.01.125
Keywords
Planarian; Homeostasis; Regeneration; DjApi5; DjAcinus
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Funding
- National Natural Science Foundation of China [31701015, 31172074]
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The study reveals the crucial roles of DjApi5 and its interacting molecule DjAcinus in planarian homeostasis and regeneration, which may be correlated with their specific localization in neoblasts and anti-apoptotic functions.
Orchestrated apoptosis in planarian Dugesia japonica is very important for its degrowth and regeneration. Apoptosis Inhibitor-5 (API5) is an anti-apoptotic factor that negatively regulates cell apoptosis. We characterized the conserved structure of DjApi5, however, the biological function of DjApi5 in planarians needs further investigation. In this study, we found that DjApi5 and its interacting molecular DjAcinus are required for planarian homeostasis, which may be correlated with their specific localization in neoblasts in addition to their anti-apoptosis functions. We further demonstrated the increased expression of DjApi5 during planarian regeneration, and DjApi5 deficiency affects normal regeneration processes. These re-sults indicated new functions of DjApi5 in development. (c) 2022 Elsevier Inc. All rights reserved.
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