LINC00624/TEX10/NF-KB axis promotes proliferation and migration of human prostate cancer cells

Prostate cancer (PCa) is a malignant epithelial tumor with a high rate of biochemical or local recurrence. Studies have suggested that LINC00624 plays an important oncogenic role in liver cancer. However, whether it exerts similar effects in PCa progression remains unknown. In this study, we explored the effects of LINC00624 on the malignant progression of PCa and sought to identify the relevant signaling pathways. The results showed that LINC00624 was highly expressed in PCa tissues and cells and was associated with poor prognosis in PCa patients. In vitro and in vivo assays further showed that LINC00624 knockdown could decrease the proliferative and migratory ability of PCa cells. Mechanistically, we found that LINC00624 and TEX10 formed a co-regulatory axis that stimulated NF-KB activity. Our data suggest that LINC00624 acts as an oncogene in PCa progression and has potential as a novel biomarker for PCa.(c) 2022 Elsevier Inc. All rights reserved.

Automated summary

The study found that LINC00624 is highly expressed in prostate cancer and is associated with poor prognosis. Knockdown of LINC00624 was found to decrease the proliferative and migratory ability of prostate cancer cells. Mechanistically, LINC00624 and TEX10 co-regulate NF-KB activity.