Hyperthermal sarcomeric oscillations generated in warmed cardiomyocytes control amplitudes with chaotic properties while keeping cycles constant

Editorial Material Physiology

Does the Hyperthermal Sarcomeric Oscillations Manifested by Body Temperature Support the Periodic Ventricular Dilation With Each Heartbeat?

Seine A. Shintani

FRONTIERS IN PHYSIOLOGY (2022)

Article Physiology

A Multiple Step Active Stiffness Integration Scheme to Couple a Stochastic Cross-Bridge Model and Continuum Mechanics for Uses in Both Basic Research and Clinical Applications of Heart Simulation

Kazunori Yoneda et al.

Summary: The study proposed a multiple time step scheme (MusAsi) to address the coupling issues between different time scales in simulating heart beats, with a focus on integrating the active tension stiffness matrix. Sensitivity analysis confirmed the accuracy and stability of the combination of MC model sample size and time step length, supporting the practicality of MusAsi for both basic research and clinical applications.

FRONTIERS IN PHYSIOLOGY (2021)

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Article Biophysics

Effects of high-pressure treatment on the structure and function of myofibrils

Seine A. Shintani

Summary: High pressure was found to affect the structure and function of myofibrils, leading to shortening and widening of the A band and structural loss in certain cases. Despite structural damage, sarcomeric oscillation could still be induced, with a decrease in total power but no change in average frequency. Restoring the original pressure also restored the average frequency.

BIOPHYSICS AND PHYSICOBIOLOGY (2021)

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Article Multidisciplinary Sciences