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Article
Biochemistry & Molecular Biology
CCDC50 suppresses NLRP3 inflammasome activity by mediating autophagic degradation of NLRP3
Yuxin Lin et al.
Summary: This study identifies a novel autophagy cargo receptor, CCDC50, which negatively regulates NLRP3 inflammasome assembly and the release of related inflammatory factors by degrading NLRP3. CCDC50 deficiency results in upregulation of signaling pathways associated with autoinflammatory diseases and enhances gut inflammation response.
EMBO REPORTS (2022)
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