Journal
AUTOPHAGY
Volume 19, Issue 2, Pages 379-387Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15548627.2022.2062112
Keywords
Acetylation; acetyltransferase; autophagy; deacetylase; post-translational modification
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This review summarizes the importance of acetylation modifications in the regulation of autophagy and their regulatory roles on multiple autophagy proteins. Acetylation regulates autophagy initiation, autophagosome formation, and transcriptional regulation by targeting core protein complexes and key regulatory molecules.
Post-translational modifications, such as phosphorylation, ubiquitination and acetylation, play crucial roles in the regulation of autophagy. Acetylation has emerged as an important regulatory mechanism for autophagy. Acetylation regulates autophagy initiation and autophagosome formation by targeting core components of the ULK1 complex, the BECN1-PIK3C3 complex, and the LC3 lipidation system. Recent studies have shown that acetylation occurs on the key proteins participating in autophagic cargo assembly and autophagosome-lysosome fusion, such as SQSTM1/p62 and STX17. In addition, acetylation controls autophagy at the transcriptional level by targeting histones and the transcription factor TFEB. Here, we review the current knowledge on acetylation of autophagy proteins and their regulations and functions in the autophagy pathway with focus on recent findings.
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