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Article
Biochemistry & Molecular Biology
SPOP mutations promote p62/SQSTM1-dependent autophagy and Nrf2 activation in prostate cancer
Qing Shi et al.
Summary: This study reveals that SPOP mutations induce non-degradative ubiquitination of p62, leading to suppression of p62-dependent autophagy and decreased Nrf2-mediated transcriptional activation of antioxidant genes, thus promoting tumor formation in SPOP-mutated PCa.
CELL DEATH AND DIFFERENTIATION (2022)
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