Thrombus formation at the inflow cannula of continuous-flow left ventricular assist devices-A systematic analysis

Article Engineering, Biomedical

Impact of anatomical position of the inflow cannula on stroke in patients with left ventricular assist devices

Takuma Takada et al.

Summary: The study found that the ratio of duct-sep distance to LV diastolic diameter was associated with the occurrence of stroke after LVAD implantation, with patients having a ratio greater than 0.217 being more prone to stroke.

INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS (2022)

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Article Engineering, Biomedical

Intraventricular Flow Patterns in Patients Treated with Left Ventricular Assist Devices

Lorenzo Rossini et al.

Summary: LVAD therapy is often complicated by issues such as thrombosis and bleeding. This study suggests that noninvasive flow imaging techniques, such as 2D echo color Doppler velocimetry, may be used alongside standard clinical methods to optimize LVAD settings and minimize blood stasis on an individual basis. LVAD support was found to reverse the increase in blood stasis associated with dilated cardiomyopathy, but did not reduce intraventricular shear exposure.

ASAIO JOURNAL (2021)

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Article Cardiac & Cardiovascular Systems

Inflow cannula obstruction of the HeartWare left ventricular assist device: what do we really know?

Federico Pappalardo et al.

Summary: This case report highlights the importance of early recognition of HVAD inflow cannula obstruction leading to in-pump thrombosis and complete cannula occlusion. Effective strategies and tools for the diagnosis and management of this complication are currently lacking.

CARDIOVASCULAR PATHOLOGY (2021)

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Article Engineering, Biomedical

Identification of characteristics, risk factors, and predictors of recurrent LVAD thrombosis: conditions in HeartWare devices

Takayuki Gyoten et al.

Summary: Recurrent HVAD thrombosis mostly occurs within 12 months after the initial event. Systemic t-PA therapy for recurrent pump thrombosis appears to be safe and achieves comparable effectiveness rates to initial t-PA therapy. Survival rates do not differ significantly between patients with or without recurrent HVAD thrombosis.

JOURNAL OF ARTIFICIAL ORGANS (2021)

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Article Cardiac & Cardiovascular Systems

Histologic features of thrombosis events with a centrifugal left ventricular assist device

Staci L. Jessen et al.

Summary: The study suggests that thrombi within HVAD pumps are commonly ingested materials rather than de novo thrombus formation within the pump. Larger thrombotic materials tend to be in the inflow region, while smaller thrombotic materials are often found within the smaller flow pathways inside the pump.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2021)

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Article Engineering, Biomedical

Multi-constituent simulation of thrombus formation at LVAD inlet cannula connection: Importance of Virchow's triad

Rodrigo Mendez Rojano et al.

Summary: This study investigates the risk of thrombosis around the VAD inlet cannula and reveals the crucial role of biochemical factors in thrombus formation, taking a step towards the long-term objective of incorporating clinically relevant pharmacological kinetics into simulations of inflow cannula thrombosis.

ARTIFICIAL ORGANS (2021)

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Article Engineering, Biomedical

Understanding the influence of left ventricular assist device inflow cannula alignment and the risk of intraventricular thrombosis

Michael Neidlin et al.

Summary: The study reveals the potential impact of inflow cannulation angles on thrombosis risk, suggesting that ideal inflow cannula alignment is towards the mitral valve and parallel to the septum. However, the optimal approach may vary depending on other patient factors and may change during the course of LVAD support.

BIOMEDICAL ENGINEERING ONLINE (2021)

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Review Oncology

Antiplatelet and anticoagulation strategies for left ventricular assist devices

Renzo Y. Loyaga-Rendon et al.

Summary: Management of antiplatelet and anticoagulation therapy is essential for optimizing outcomes in patients with LVAD. Understanding the device, patient factors, and various treatment options for complications such as bleeding and thrombosis is crucial for successful management of LVAD patients.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

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Article Engineering, Biomedical

Pump position and thrombosis in ventricular assist devices: Correlation of radiographs and CT data

Philipp Aigner et al.

Summary: Identifying malpositioning of left ventricular assist devices (LVAD) from clinical imaging remains challenging, but parameters correlating to pump thrombosis can be identified through X-rays and CT scans. Different types of LVAD patients show different characteristics in X-rays and CT scans.

INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS (2021)

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Article Engineering, Biomedical

Left Ventricular Assist Device Inflow Cannula Insertion Depth Influences Thrombosis Risk

Venkat Keshav Chivukula et al.

ASAIO JOURNAL (2020)

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Article Cardiac & Cardiovascular Systems

HeartWare Ventricular Assist Device Cannula Position and Hemocompatibility-Related Adverse Events

Teruhiko Imamura et al.

ANNALS OF THORACIC SURGERY (2020)

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Article Cardiac & Cardiovascular Systems

Understanding risk factors and predictors for stroke subtypes in the ENDURANCE trials

Sung-Min Cho et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2020)

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Article Engineering, Biomedical

The influence of left ventricular assist device inflow cannula position on thrombosis risk

Mojgan Ghodrati et al.

ARTIFICIAL ORGANS (2020)

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Article Engineering, Biomedical

High-speed visualization of ingested, ejected, adherent, and disintegrated thrombus in contemporary ventricular assist devices

Grant W. Rowlands et al.

ARTIFICIAL ORGANS (2020)

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Article Engineering, Biomedical

The Effect of Inflow Cannula Angle on the Intraventricular Flow Field of the Left Ventricular Assist Device-Assisted Heart: An In Vitro Flow Visualization Study

Karen May-Newman et al.

ASAIO JOURNAL (2019)

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Article Engineering, Biomedical

Small Left Ventricular Size Is an Independent Risk Factor for Ventricular Assist Device Thrombosis

Venkat Keshav Chivukula et al.

ASAIO JOURNAL (2019)

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Article Cardiac & Cardiovascular Systems

Thrombus on the inflow cannula of the HeartWare HVAD: an update

Carolyn H. Glass et al.

CARDIOVASCULAR PATHOLOGY (2019)

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Article Cardiac & Cardiovascular Systems

Prothrombotic activity of cytokine-activated endothelial cells and shear-activated platelets in the setting of ventricular assist device support

Alice Apostoli et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2019)

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Article Engineering, Biomedical

Left Ventricular Hemodynamics with an Implanted Assist Device: An In Vitro Fluid Dynamics Study

Francesco Viola et al.

ANNALS OF BIOMEDICAL ENGINEERING (2019)

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Review Physiology

WOUND HEALING: A CELLULAR PERSPECTIVE

Melanie Rodrigues et al.

PHYSIOLOGICAL REVIEWS (2019)

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Article Engineering, Biomedical

International Analysis of LVAD Point-of-Care Versus Plasma INR: A Multicenter Study

Sarah Schettle et al.

ASAIO JOURNAL (2018)

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Article Materials Science, Biomaterials

Honeycomb-structured metasurfaces for the adaptive nesting of endothelial cells under hemodynamic loads

Bjoern Johann Bachmann et al.

BIOMATERIALS SCIENCE (2018)

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Article Cardiac & Cardiovascular Systems

Left Ventricular Assist Device Malfunctions It Is More Than Just the Pump

Robert L. Kormos et al.

CIRCULATION (2017)

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Article Engineering, Biomedical

The Effect of Inflow Cannula Length on the Intraventricular Flow Field: An In Vitro Flow Visualization Study Using the Evaheart Left Ventricular Assist Device

Karen May-Newman et al.

ASAIO JOURNAL (2017)

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Letter Cardiac & Cardiovascular Systems

Thrombus around the redesigned HeartWare HVAD inflow cannula: A pathologic case series

Kyle C. Strickland et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2016)

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Article Engineering, Biomedical

LVAD inflow cannula covered with a titanium mesh induces neointimal tissue with neovessels

Takuma Miyamoto et al.

INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS (2015)

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Article Cardiac & Cardiovascular Systems

Design changes in continuous-flow left ventricular assist devices and life-threatening pump malfunctions

Sajjad Soltani et al.

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY (2015)

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Article Engineering, Biomedical

The influence of surface micro-structure on endothelialization under supraphysiological wall shear stress

Francesco Robotti et al.

BIOMATERIALS (2014)

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Article Cardiac & Cardiovascular Systems

An analysis of pump thrombus events in patients in the Heart Ware ADVANCE bridge to transplant and continued access protocol trial

Samer S. Najjar et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2014)

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Article Cardiac & Cardiovascular Systems

In Vitro Evaluation of Ventricular Cannulation for Rotodynamic Cardiac Assist Devices

Timothy N. Bachman et al.

Cardiovascular Engineering and Technology (2011)

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Letter Cardiac & Cardiovascular Systems

DEVELOPMENT OF AN EX VIVO OVINE VENTRICULAR ASSIST DEVICE MODEL FOR INTRAVENTRICULAR VISUALIZATION OF THE INFLOW CANNULA

Jay K. Bhama et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2009)

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Article Cardiac & Cardiovascular Systems

Influence of inflow cannula length in axial-flow pumps on neurologic adverse event rate:: Results from a multi-center analysis

Christof Schmid et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2008)

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Article Engineering, Biomedical

Microtextured materials for circulatory support devices: Preliminary studies

CM Zapanta et al.

ASAIO JOURNAL (2006)

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Article Cardiac & Cardiovascular Systems

First clinical experience with the DeBakey VAD continuous-axial-flow pump for bridge to transplantation

GM Wieselthaler et al.

CIRCULATION (2000)

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Thrombus formation at the inflow cannula of continuous-flow left ventricular assist devices-A systematic analysis

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