4.4 Article

Genome sequence of Corynebacterium amycolatum ICIS 99 isolated from human vagina reveals safety and beneficial properties

Journal

ARCHIVES OF MICROBIOLOGY
Volume 204, Issue 4, Pages -

Publisher

SPRINGER
DOI: 10.1007/s00203-022-02852-7

Keywords

Corynebacterium amycolatum; Draft genome sequence; Secondary metabolites; Vaginal microbiome

Categories

Ask authors/readers for more resources

Corynebacterium amycolatum ICIS 99, isolated from vaginal smears of healthy women, exhibits promising antimicrobial activity. The genome analysis reveals that ICIS 99 lacks true virulence factors but possesses genes that contribute to adaptation and survival in the vaginal environment. The genomic information lays the foundation for evaluating the safety and useful properties of ICIS 99 as a potential probiotic strain.
Corynebacterium amycolatum ICIS 99 was isolated from vaginal smears of healthy women and showed promising results in antimicrobial screenings. Here, we report the draft genome sequence of this strain and analyze its main features to assess its safety and useful properties. The genome is 2,532,503 bp long and contains 2186 CDSs with an average G + C content of 59.0%. Analyses of the ICIS 99 genome revealed the absence of true virulence factors. The genome contains genes involved in the synthesis of secondary metabolites and bacteriocins of the class sactipeptide. In the genome of ICIS 99, we identified a large number of genes responsible for adaptation and survival in the vaginal environment, including acid and oxidative stress resistance genes. The genomic information of ICIS 99 provides a basis for understanding the safety and useful properties of ICIS 99 and for considering it as a potential probiotic strain. The whole genome shotgun project has been deposited at DDBJ/ENA/GenBank under the accession number JAIUSU000000000.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.4
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available