Readmissions due to hyperemesis gravidarum: a nation-wide Finnish register study

Purpose To evaluate the burden of illness caused by hyperemesis gravidarum (HG) and association of readmissions due to HG with maternal, environmental and pregnancy-related factors, and different pregnancy outcomes. Methods Data of women with HG diagnosis in Finland, 2005-2017, were retrieved from health-care registers. Associations between readmissions due to HG and age, gravidity, parity, pre-pregnancy body mass index (BMI), smoking, marital status, socioeconomic status, municipality population, assisted reproductive technology (ART), and number and sex of fetuses were analyzed in pregnancies resulting in delivery. Admissions and readmissions due to HG in deliveries, gestational trophoblastic disease, ectopic pregnancies, miscarriages and pregnancy terminations were calculated. Results 10,381 pregnancies with HG diagnosis were identified: 9518 live births, 31 stillbirths, 8 cases of gestational trophoblastic disease, 16 ectopic pregnancies, 299 miscarriages, and 509 pregnancy terminations. Both outpatients and inpatients were included. Readmission occurred in 60% of pregnancies, inpatient readmission in 17%. Parity of >= 5, multiple gestation and female sex of fetus were associated with higher odds of readmission, maternal age 36-40 years, BMI >= 35 kg/m(2), smoking and ART with lower odds of readmission. Of the 9549 pregnancies resulting in delivery, 33% involved at least one outpatient visit or inpatient episode after the first trimester, and 8% in the third trimester. Conclusion The majority of women suffering from HG needed repeated medical care, often persisting after the first trimester. Our results provide practical information allowing clinicians to prepare for symptom duration beyond the first trimester and emphasize the importance of planning for eventual long-term treatment.

Automated summary

This study evaluated the burden of illness caused by hyperemesis gravidarum (HG) and its association with readmissions. The majority of women with HG required repeated medical care and factors such as multiple gestation, high parity, and female fetus were associated with higher odds of readmission. On the other hand, factors like maternal age, pre-pregnancy BMI, smoking, and assisted reproductive technology were related to lower odds of readmission.