Journal
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
Volume 128, Issue 6, Pages -Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00339-022-05612-y
Keywords
Nanocarrier; Quercetin; Biocompatibility; Drug delivery
Funding
- Ministry of Science, Research and Technology, Malayer University of Iran
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In this study, spinel ferrite nanocarriers with different concentrations were fabricated and their structural characteristics, physical properties, drug release behavior, and cytotoxicity were studied. The results showed variations in drug release behavior and cellular activity for different concentrations of nanocarriers.
In this study, spinel ferrite nanocarriers Ca1-xMnxFe2O4 (0 < x < 1) were fabricated by thermal treatment at 873 K. Different techniques were used to study of structural characteristics and physical properties of ferrite nanocarriers in various concentrations. The highest drug loading was in the x = 0.4 sample and the lowest was observed in the x = 0.6 and x = 0.8 samples. The rapid initial release of Quercetin (Que) occurred at both pH values (5.5 and 7.4), which may be due to the diffusion of Que bound to the surface of nanocarriers (NCs). Although each nanocarrier had its release behavior, with decreased pH from 7.4 to 5.5, the values of Que release percentage increased and x = 0.8 and x = 0.6 samples showed the highest release percentage in both media. The cytotoxicity of NCs and Que-loaded on NCs against HEK 293-T human cells was investigated using the MTT assay. Mild cellular activity of x = 0, x = 0.2, and x = 0.4 NCs may have resulted from Que phenoxyl radicals. The cell viability of cancer cells was examined using the MTT method that was different for each sample at different concentrations, the proliferation of MCF-7 cells was prevented in a dose-dependent manner up by increasing the concentration to 60 mu g/ml. The percent hemolytic activity of NCs was also determined by hemolysis assay, but no significant hemolytic activity was observed.
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