Journal
APPLIED ORGANOMETALLIC CHEMISTRY
Volume 36, Issue 7, Pages -Publisher
WILEY
DOI: 10.1002/aoc.6743
Keywords
1H-imidazole; 2-methylquinoline; arylboronic acid; copper(II) complexes; cyclic secondary amines
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Funding
- Natural Science Foundation of Shanxi Province [201901D111276]
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In this study, three copper complexes were synthesized and used in the construction of C-N bonds. Among them, complex II displayed higher activity in the reaction compared to the other two complexes. The reaction showed advantages such as a wide scope of substrates, high yields, and mild reaction conditions.
Three copper(II) complexes (I-III) bearing N,O-bidentate ligands (L-1-L-3), derived from 2-methylquinoline and cyclic secondary amines (including pyrrolidine, morpholine, and 4-methylpiperidine), were successfully prepared and successively employed in construction of C-N bonds via the Chan-Lam coupling of 1H-imidazole derivatives with arylboronic acids. X-ray diffraction analysis demonstrated that the central copper(II) atom of II adopted the distorted tetrahedral geometry, which was four coordinated by one nitrogen atom and one oxygen atom from L-2 as well as two chloride atoms. Catalytic studies indicated that complex II displayed higher activity in Chan-Lam reaction than complex I or III. The present protocol for N,O-coordinated-copper complex-catalyzed C-N coupling reaction exhibited some advantages such as wide scope of substrates, good yields, and mild conditions.
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