Cu microcrystals garnished with copper nanoparticles catalyzed one-pot facile synthesis of novel 1,2,3-triazoles via click chemistry as antifungal agents

A remarkable, efficacious, and environmental friendly one-pot procedure affianced for the synthesis of 1,2,3-triazoles by 1,3-dipolar cycloaddition of aromatic azides, terminal alkynes over Cu microcrystals (CuMCs) by click chemistry as subsequent way. The predominance of this method is green synthetic pathway, transient reaction times, facile workup, exceptional yields (87% to 90%) with excellent purity, regioselective single product formation, and eco-friendliness of the CuMCs catalyst. Docking studies manifested strong binding interactions with enzyme sterol 14-alpha-demethylase (PDB ID: 3KHM) with excellent C-score values. The antifungal screening of synthesized compounds revealed promising activity.

Automated summary

A green and efficient method for the synthesis of 1,2,3-triazoles was developed using click chemistry on copper microcrystals. The method showed short reaction times, high yields, and excellent purity, with a catalyst that is environmentally friendly. The synthesized compounds exhibited promising antifungal activity.