Pharmacodynamics of Meropenem and Tobramycin for Neonatal Meningoencephalitis: Novel Approaches to Facilitate the Development of New Agents to Address the Challenge of Antimicrobial Resistance

Review Immunology

A Regulatory Review Approach for Evaluation of Micafungin for Treatment of Neonatal Candidiasis

Gillian Taormina et al.

Summary: The pathogenesis of neonatal candidiasis differs from systemic candidiasis in adults, with a higher incidence of central nervous system involvement. While clinical trials for neonatal candidiasis are challenging, it is important to address the unmet need for effective treatment in this population. A regulatory review approach has been described to guide the use of micafungin in pediatric patients younger than 4 months, while acknowledging areas of uncertainty in labeling.

CLINICAL INFECTIOUS DISEASES (2021)

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Article Microbiology

Amikacin Combined with Fosfomycin for Treatment of Neonatal Sepsis in the Setting of Highly Prevalent Antimicrobial Resistance

Christopher A. Darlow et al.

Summary: Antimicrobial resistance in neonatal sepsis is a global issue, with high mortality rates in low- and middle-income countries. A combination therapy of fosfomycin and amikacin shows enhanced bactericidal activity and synergy against resistant strains. Monte Carlo simulations support the efficacy of this combination regimen for the treatment of neonatal sepsis.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2021)

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Article Infectious Diseases

Effects of antibiotic resistance, drug target attainment, bacterial pathogenicity and virulence, and antibiotic access and affordability on outcomes in neonatal sepsis: an international microbiology and drug evaluation prospective substudy (BARNARDS)

Kathryn M. Thomson et al.

Summary: When advocating antibiotic treatments, accessibility and affordability must be considered, tailored to the variance in economic health structures across low- and middle-income countries. Funding comes from The Bill & Melinda Gates Foundation. This article is published under an Open Access license.

LANCET INFECTIOUS DISEASES (2021)

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Article Infectious Diseases