Association of Matrix Metallopeptidase-2 Genotypes With Risk of Gastric Cancer in Taiwan

Background/Aim: Matrix metalloproteinase-2 (MMP-2) plays a critical role in the regulation of the extracellular matrix; however, its genotypes have seldom been examined in gastric cancer (GC). This study aimed to investigate the contribution of MMP-2 promoter-1306 (rs243865) and-735 (rs2285053) genotypes to GC risk in a cohort of Taiwanese individuals. Materials and Methods: This study included 121 GC cases and 363 age-and sex-matched controls. The genotypes of MMP-2 were determined by typical polymerase chain reaction-restriction fragment length polymorphism. Results: The genotypic and allelic frequency analysis showed that MMP-2 rs243865 variant genotypes decreased the risk of GC. Stratification analysis showed that MMP-2 rs243865 genotypes associate with smoking, alcohol drinking, and Helicobacter pylori infection status to confer personal susceptibility to GC. There is no such association for MMP-2 rs2285053 genotype with GC risk. Conclusion: The MMP-2 rs243865 genotypes may serve as a novel predictive marker for GC personal susceptibility among Taiwanese.

Automated summary

This study found that the MMP-2 rs243865 genotype decreased the risk of GC in the Taiwanese population and was associated with smoking, alcohol drinking, and Helicobacter pylori infection status.