4.4 Review

Drug Repurposing Strategies for Non-cancer to Cancer Therapeutics

Journal

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
Volume 22, Issue 15, Pages 2726-2756

Publisher

BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1871520622666220317140557

Keywords

Anticancer drugs; multitargeting; Non-cancer drugs; drug repurposing; drug discovery; cancer therapeutics

Funding

  1. [AKTU/Dean-PGSR/PhD/2019/5738]

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Drug repurposing is an effective approach to repurpose clinically approved noncancer drugs with known targets for the treatment of cancer. Various types of noncancer drugs have shown promising outcomes in preclinical and clinical phases.
Global efforts invested in the prevention and treatment of cancer need to be repositioned to develop safe, effective, and economic anticancer therapeutics by adopting rational approaches of drug discovery. Drug repurposing is one of the established approaches to reposition old, clinically approved off-patent noncancer drugs with known targets into newer indications. The literature review suggests a key role of drug repurposing in the development of drugs intended for cancer as well as noncancer therapeutics. A wide category of noncancer drugs such as, drugs acting on CNS, anthelmintics, cardiovascular drugs, antimalarial drugs, anti-inflammatory drugs, have come out with interesting outcomes during preclinical and clinical phases. In the present article, a comprehensive overview of the current scenario of drug repurposing for the treatment of cancer has been focused. The details of some successful studies along with examples have been included followed by associated challenges.

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