Intraluminal Thrombus and Abdominal Aortic Aneurysm Complications

Article Surgery

Real-Time Evaluation of Blood Flow Patterns Using AneurysmFlow for an in vivo Abdominal Aortic Aneurysm Model

Young Jun Park et al.

Summary: This study used the novel flow evaluation system AneurysmFlow to analyze blood flow patterns and velocities in an in vivo AAA model, finding a close correlation with the lumen occupying ratio of intraluminal thrombus. This analytic approach has the potential to provide clinically meaningful hemodynamic information of AAA.

ANNALS OF VASCULAR SURGERY (2022)

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Article Biochemistry & Molecular Biology

AAA Revisited: A Comprehensive Review of Risk Factors, Management, and Hallmarks of Pathogenesis

Veronika Kessler et al.

Summary: Abdominal aortic aneurysm (AAA) is a life-threatening cardiovascular condition, with a prevalence of about 2-3% in the industrialized world. Older men with a history of smoking are at a higher risk for developing AAA. Screening programs can help detect and prevent ruptures of the aorta, which have a high associated death rate.

BIOMEDICINES (2022)

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Article Biophysics

Mechanical role of intraluminal thrombus in aneurysm growth: A computational study

Nino Horvat et al.

Summary: ILT deposition in abdominal aortic aneurysms (AAAs) helps to slow down growth by redirecting blood pressure loading from axial-radial plane to predominantly radial direction. The ratio of ILT volume to volume sac is an important factor in AAA stabilization, with fully thrombosed aneurysms stabilizing quicker and at smaller maximum diameters compared to partially thrombosed ones. However, ILT formation and the associated mural stress decrease negatively impact the wall constituent production and thickness.

BIOMECHANICS AND MODELING IN MECHANOBIOLOGY (2021)

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Article Multidisciplinary Sciences

Geometric and biomechanical modeling aided by machine learning improves the prediction of growth and rupture of small abdominal aortic aneurysms

Moritz Lindquist Liljeqvist et al.

Summary: Geometric and biomechanical analysis improved the accuracy of predicting reaching surgical threshold within four years and diameter growth rate, mainly due to semi-automatic diameter measurements. Enhanced precision of diameter measurements improves the ability to predict reaching the surgical threshold and diameter growth rate, while lumen diameter and biomechanical analysis predict rupture or symptomatic AAA.

SCIENTIFIC REPORTS (2021)

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Article Surgery