Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 90, Issue -, Pages 69-80Publisher
ELSEVIER
DOI: 10.1016/j.addr.2015.04.001
Keywords
Detoxification; Virulence factors; Anti-toxin nanoparticles; Liposomes; Cell membranes; Nanosponges
Categories
Funding
- National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health [R01DK095168]
- Defense Threat Reduction Agency Joint Science and Technology Office for Chemical and Biological Defense [HDTRA1-14-1-0064]
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Protein toxins secreted from pathogenic bacteria and venomous animals rely on multiple mechanisms to overcome the cell membrane barrier to inflict their virulence effect. A promising therapeutic concept toward developing a broadly applicable anti-toxin platform is to administer cell membrane mimics as decoys to sequester these virulence factors. As such, lipid membrane-based nanoparticulates are an ideal candidate given their structural similarity to cellular membranes. This article reviews the virulence mechanisms employed by toxins at the cell membrane interface and highlights the application of cell-membrane mimicking nanoparticles as toxin decoys for systemic detoxification. In addition, the implication of particle/toxin nanocomplexes in the development of toxoid vaccines is discussed. (C) 2015 Elsevier B.V. All rights reserved.
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