Journal
ANNALS OF EPIDEMIOLOGY
Volume 69, Issue -, Pages 27-33Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.annepidem.2022.02.006
Keywords
Maternal asthma; Asthma severity; Spontaneous abortion; Miscarriage
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Funding
- Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institute of Health [R01 HD086742]
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The study found that there was no significant association between a history of asthma and the incidence of spontaneous abortion (SAB), but severe asthma (based on medication use) was associated with a higher risk of SAB.
Purpose: To evaluate the relationships among history of asthma, asthma severity, and spontaneous abortion (SAB). Methods: Pregnancy Study Online is a preconception cohort study of North American couples. During the preconception period, female participants reported their history of physician-diagnosed asthma, age at first diagnosis, and use of asthma medications in the previous 4 weeks. Asthma severity was classified by medication use proximal to conception, from level 0 to 3 in increasing severity. Pregnancy and SAB were identified using data from follow-up questionnaires. We estimated hazard ratios (HRs) and 95% confidence intervals (CIs). Results: Among 6325 participants who conceived, 19% experienced SAB and 17% reported a history of asthma. There was no appreciable association between asthma history and SAB incidence (HR = 0.98; 95% CI: 0.84, 1.14). HRs comparing severity levels 0, 1, and 2-3 with no asthma were 0.82 (95% CI: 0.67, 1.01), 1.20 (95% CI: 0.91, 1.60), and 1.31 (95% CI: 0.97, 1.78), respectively. Among women who conceived without the use of fertility treatment, level 2-3 severity was associated with SAB (HR = 1.39; 95% CI: 1.02, 1.89). Conclusions: While history of asthma diagnosis was not materially associated with SAB, having severe asthma (based on medication use) was associated with greater SAB risk. (c) 2022 Elsevier Inc. All rights reserved.
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