Biphasic squamoid alveolar renal cell carcinoma: Cytologic features of a rare entity

Biphasic squamoid alveolar renal cell carcinoma is a newly described rare morphologic variant of papillary renal cell carcinoma. Its characteristic histomorphology and immunophenotype have been well described in the literature. Namely, BSARCC is composed of a dual-cell population with nests of larger squamoid cells surrounded by a single layer of cuboidal cells in alveolar arrangements. Invariably, the squamoid component expresses cyclin D1. More recently, MET alterations have been identified within a subset of BSARCC, raising the possibility for targeted MET inhibitor therapy. To the best of our knowledge the cytomorphologic features of BSARCC have yet to be described. Herein we correlate the cytologic features (percutaneous image-guided fine needle aspiration) of BSARCC to its corresponding histomorphology and immunophenotype (core needle biopsy).

Automated summary

Biphasic squamoid alveolar renal cell carcinoma is a rare variant of papillary renal cell carcinoma with distinct histomorphology and immunophenotype. The cytomorphologic features of this type of carcinoma have not been described. This study correlates the cytologic features with histomorphology and immunophenotype, providing new insights into this disease.