4.5 Editorial Material

Special Issue of the VPH2020 Conference: Virtual Physiological Human: When Models, Methods and Experiments Meet the Clinic

Related references

Note: Only part of the references are listed.
Article Engineering, Biomedical

The Effects of Micro-vessel Curvature Induced Elongational Flows on Platelet Adhesion

Christian J. Spieker et al.

Summary: The study investigated the effects of channel curvature on cellular blood flow, finding significant differences in shear rate values and distributions between the inner and outer arc of the channel curve, while cell distributions remained largely unaffected. Additionally, the inner side of the arc showed increased platelet adhesion intensity at high wall shear rates.

ANNALS OF BIOMEDICAL ENGINEERING (2021)

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Pre-surgical Prediction of Ischemic Mitral Regurgitation Recurrence Using In Vivo Mitral Valve Leaflet Strains

Harshita Narang et al.

Summary: Research shows that there are significant differences in pre-surgical mitral valve size, shape, and deformation patterns between patients with and without IMR recurrence at 6 months post-surgery. Average pre-surgical circumferential leaflet strain in the A1 region can independently predict IMR recurrence.

ANNALS OF BIOMEDICAL ENGINEERING (2021)

Article Engineering, Biomedical

In Vitro Measurements of Shear-Mediated Platelet Adhesion Kinematics as Analyzed through Machine Learning

Jawaad Sheriff et al.

Summary: In this study, a semi-unsupervised learning system (SULS) was used to segment platelet geometry and analyze their flipping kinematics in shear flow. It was found that flipping platelets exhibit characteristics different from previously-modeled orbits, with a longer lift-off and shorter reattachment period. The study demonstrated the importance of accurately capturing platelet motion for validating models of shear-mediated thrombosis.

ANNALS OF BIOMEDICAL ENGINEERING (2021)

Article Engineering, Biomedical

In Silico Clinical Trials in the Orthopedic Device Industry: From Fantasy to Reality?

Philippe Favre et al.

Summary: This article discusses how the orthopedic device industry relies on clinical evaluation for safety and performance confirmation, as well as the potential benefits and challenges of virtual in silico clinical trials (ISCT). It emphasizes the importance of defining patient risks, using versatile software pipelines, ensuring model credibility, and limiting regulatory uncertainty for the successful implementation of ISCT as a complementary strategy to traditional clinical trials.

ANNALS OF BIOMEDICAL ENGINEERING (2021)

Article Engineering, Biomedical

Automated Framework for the Inclusion of a His-Purkinje System in Cardiac Digital Twins of Ventricular Electrophysiology

Karli Gillette et al.

Summary: Personalized models known as cardiac digital twins (CDTs) have shown promise in tailoring cardiac precision therapies, with a recent study developing an automated two-stage approach for personalization of the His-Purkinje system (HPS). By comparing activation patterns and ECGs, both HPS models were found to preserve predominant ECG morphology under sinus conditions but revealed differences during pacing.

ANNALS OF BIOMEDICAL ENGINEERING (2021)

Article Engineering, Biomedical

Multiscale Coupling of One-dimensional Vascular Models and Elastic Tissues

Luca Heltai et al.

Summary: This study introduces a computational multiscale model for simulating vascularized tissues efficiently, comprising an elastic matrix and a vascular network. The model is capable of reproducing tissue responses at the effective scale while modeling microscale vasculature.

ANNALS OF BIOMEDICAL ENGINEERING (2021)

Article Engineering, Biomedical

Effect of Suboptimal Neuromuscular Control on the Risk of Massive Wear in Total Knee Replacement

Marco Viceconti et al.

Summary: Neuromuscular control during walking affects joint loading and implant wear in total knee replacement patients, especially those with Parkinson's Disease. Suboptimal control strategies increase the risk of implant failure, but further research is needed to determine if other failure modes are involved.

ANNALS OF BIOMEDICAL ENGINEERING (2021)

Article Engineering, Biomedical

Experimental Validation of Enhanced Magnetic Resonance Imaging (EMRI) Using Particle Image Velocimetry (PIV)

Giacomo Annio et al.

Summary: The integration of four-dimensional flow-sensitive cardiovascular magnetic resonance imaging (4D Flow CMR) with computational fluid dynamics (CFD) in Enhanced 4D Flow CMR (EMRI) overcomes spatial resolution limitations, enabling accurate flow quantification and showing better agreement with experimental results compared to traditional techniques.

ANNALS OF BIOMEDICAL ENGINEERING (2021)

Article Engineering, Biomedical

On the Sensitivity Analysis of Porous Finite Element Models for Cerebral Perfusion Estimation

T. Jozsa et al.

Summary: Computational physiological models are promising tools for enhancing clinical trial design and decision making. This study established guidelines for the usage of a three-dimensional steady state porous cerebral perfusion model and validated its reliability and applicability in ischaemic stroke patients.

ANNALS OF BIOMEDICAL ENGINEERING (2021)

Article Engineering, Biomedical

Effects of Uncertainty of Outlet Boundary Conditions in a Patient-Specific Case of Aortic Coarctation

Maria Nicole Antonuccio et al.

Summary: CFD simulations of blood flow play an important role in cardiovascular studies, with accuracy depending on the certainty of input parameters. Propagating uncertainty from clinical data to model results allows estimation of model prediction confidence. In a patient-specific aortic coarctation model, Windkessel models as outflow boundary conditions and stochastic analysis were used to evaluate the impact of uncertain parameters.

ANNALS OF BIOMEDICAL ENGINEERING (2021)

Article Engineering, Biomedical

A Mesoscale Computational Model for Microvascular Oxygen Transfer

Luca Possenti et al.

Summary: This study introduces a mathematical model for oxygen transfer in microcirculation and validates its applicability. The model can describe the heterogeneity of oxygenation in the tissue microenvironment. The study also discusses the importance of these effects in the treatment of cancer using radiotherapy.

ANNALS OF BIOMEDICAL ENGINEERING (2021)

Article Engineering, Biomedical

Parametric Analysis of an Integrated Model of Cardio-respiratory Interactions in Adults in the Context of Obstructive Sleep Apnea

Gustavo Guerrero et al.

Summary: This paper presents an original integrated model of cardio-respiratory interactions to study the acute physiological responses evoked by obstructive sleep apnea events in adults. A sensitivity analysis of the model highlights key parameters related to physiology, providing valuable information for the development of novel diagnostic and therapeutic strategies. The results suggest significant physiological variables that may be particularly useful for integrating a virtual patient approach.

ANNALS OF BIOMEDICAL ENGINEERING (2021)

Article Engineering, Biomedical

On the Periodicity of Cardiovascular Fluid Dynamics Simulations

Martin R. Pfaller et al.

Summary: In this study, an asymptotic error measurement was proposed to quantify the difference between simulation results and their ideal periodic state in three-dimensional cardiovascular fluid dynamics simulations. The use of automatically generated initial conditions significantly reduced computation time and achieved periodic convergence within a few cardiac cycles, leading to a substantial decrease in computational cost. Initial conditions were shown to be crucial in reducing computational time, and an automated framework for generating appropriate initial conditions was developed.

ANNALS OF BIOMEDICAL ENGINEERING (2021)

Article Engineering, Biomedical

Mechanical Effects of a Maylard Scar During a Vaginal Birth After a Previous Caesarean

D. S. Fidalgo et al.

Summary: Caesarean section is a common surgery worldwide, but its long-term benefits for mothers and babies are not supported by evidence. This study aims to investigate the biomechanical influences of Maylard fiber reorientation and stiffness on the uterine scar during vaginal birth after caesarean (VBAC) through computational methods. The results indicate that the arrangement of scar fibers in the Maylard scar has a significant impact on its mechanical behavior during a VBAC, with an increase in matrix scar stiffness showing a lesser impact.

ANNALS OF BIOMEDICAL ENGINEERING (2021)

Article Engineering, Biomedical

Assessing Early Cardiac Outflow Tract Adaptive Responses Through Combined Experimental-Computational Manipulations

Stephanie E. Lindsey et al.

Summary: Mechanical forces play a crucial role in the growth and remodeling of primitive pharyngeal arch arteries into the heart's great vessels. However, the direct correlation between hemodynamics and PAA morphogenesis has been poorly understood. A study using minimally invasive occlusion experiments in avian embryos and 3D anatomical models revealed significant changes in morphology and hemodynamics following vessel occlusion, providing insights into the dynamic vessel adaptation process.

ANNALS OF BIOMEDICAL ENGINEERING (2021)