Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 61, Issue 29, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202203893
Keywords
Alcohol Hydration; Entropy; Enthalpy; Hydrophobic Hydration; THz-Calorimetry; THz Spectroscopy
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Funding
- European Research Council (ERC) [695437]
- Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany's Excellence Strategy [EXC2033-390677874-RESOLV]
- Mercator Research Center Ruhr (MERCUR)
- European Union [FP-RESOMUS -MSCA 801459]
- Center for Solvation Science ZEMOS - German Federal Ministry of Education and Research BMBF
- Ministry of Culture and Research of Nord Rhine-Westphalia MKW NRW
- Projekt DEAL
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Hydration free energies are determined by the delicate balance between hydrophobic and hydrophilic interactions. A spectroscopic approach using THz spectroscopy allows direct access to the contributions of cavity formation and hydrophilic interactions, and enables the separate determination of the thermodynamic effects of hydrophobic and hydrophilic interactions.
Hydration free energies are dictated by a subtle balance of hydrophobic and hydrophilic interactions. We present here a spectroscopic approach, which gives direct access to the two main contributions: Using THz-spectroscopy to probe the frequency range of the intermolecular stretch (150-200 cm(-1)) and the hindered rotations (450-600 cm(-1)), the local contributions due to cavity formation and hydrophilic interactions can be traced back. We show that via THz calorimetry these fingerprints can be correlated 1 : 1 with the group specific solvation entropy and enthalpy. This allows to deduce separately the hydrophobic (i.e. cavity formation) and hydrophilic contributions to thermodynamics, as shown for hydrated alcohols as a case study. Accompanying molecular dynamics simulations quantitatively support our experimental results. In the future our approach will allow to dissect hydration contributions in inhomogeneous mixtures and under non-equilibrium conditions.
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