An endo-Directing-Group Strategy Unlocks Enantioselective (3+1+2) Carbonylative Cycloadditions of Aminocyclopropanes

An endo-directing group strategy enables enantioselective (3+1+2) cycloadditions that are triggered by carbonylative C-C bond activation of cyclopropanes. These processes are rare examples of cycloadditions where C-C bond oxidative addition is enantiodetermining, and the first where this is achieved within the context of a multicomponent (higher order) reaction design.

Automated summary

An enantioselective (3+1+2) cycloaddition reaction triggered by carbonylative C-C bond activation of cyclopropanes is achieved using an endo-directing group strategy. This reaction represents a rare example where C-C bond oxidative addition determines the enantiomeric outcome, and it is the first time this has been achieved within the context of a multicomponent reaction design.