Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 61, Issue 31, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202117229
Keywords
Cancer Imaging; Cancer Therapy; Ferroptosis; High-Field MRI; Ternary Alloy Nanocubes
Categories
Funding
- National Natural Science Foundation of China [U21A20287, 51872088, 21890744, 21974039]
- National Key R&D Program of China [2019YFA0210100]
- Science and Technology Project of Hunan Province [2020RC3022, 2020SK2014]
Ask authors/readers for more resources
Researchers have developed a novel nanoplatform for ferroptosis therapy and can monitor the process in real-time using high-field MRI.
Ferroptosis exhibits potential to damage drug-resistant cancer cells. However, it is still restricted with the off-target toxicity from the undesirable leakage of metal ions from ferroptosis agents, and the lack of reliable imaging for monitoring the ferroptosis process in living systems. Herein, we develop a novel ternary alloy PtWMn nanocube as a Mn reservoir, and further design a microenvironment-triggered nanoplatform that can accurately release Mn ions within the tumor to increase reactive oxygen species (ROS) generation, produce O-2 and consume excess glutathione for synergistically enhancing nonferrous ferroptosis. Moreover, this nanoplatform exerts a responsive signal in high-field magnetic resonance imaging (MRI), which enables the real-time report of Mn release and the monitoring of ferroptosis initiation through the signal changes of T-1-/T-2-MRI. Thus, our nanoplatform provides a novel strategy to store, deliver and precisely release Mn ions for MRI-guided high-specificity ferroptosis therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available