Journal
ANESTHESIA AND ANALGESIA
Volume 135, Issue 6, Pages 1253-1261Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1213/ANE.0000000000005971
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Infiltration of ropivacaine and Diprospan as an adjuvant to local anesthetic can achieve satisfactory postoperative pain relief after craniotomy. This technique is simple, easy, and safe, and deserves clinical promotion.
BACKGROUND: Preemptive injection of local anesthetics can prevent postoperative pain at the incision site, but the analgesic effect is insufficient and is maintained only for a relatively short period of time. Diprospan is a combination of quick-acting betamethasone sodium phosphate and long-acting betamethasone dipropionate. Whether Diprospan as an adjuvant to local anesthetic can achieve postcraniotomy pain relief has not been studied yet. METHODS: This is a prospective, single-center, blinded, randomized, controlled clinical study, which included patients ages 18 and 64 years, with American Society of Anaesthesiologists (ASA) physical statuses of I to III, scheduled for elective supratentorial craniotomy. We screened patients for enrollment from September 3, 2019, to August 15, 2020. The final follow-up was completed on February 15, 2021. Eligible patients were randomly assigned to either the Diprospan group, who received incision-site infiltration of 0.5% ropivacaine plus Diprospan (n = 48), or the control group, who received 0.5% ropivacaine alone (n = 48), with a distribution ratio of 1:1. Primary outcome was the cumulative sufentanil (mu g) consumption through patient-controlled analgesia (PCA) within 48 hours after surgery. Primary analysis was performed based on the intention-to-treat (ITT) principle. RESULTS: Baseline characteristics were not significantly different between the 2 groups (P >.05). In the Diprospan group, the cumulative sufentanil consumption through PCA was 5 (0-16) mu g within 48 hours postoperatively, which was significantly lower than that in the control group (38 [30.5-46] mu g; P <.001). CONCLUSIONS: Infiltration of ropivacaine and Diprospan can achieve satisfactory postoperative pain relief after craniotomy; it is a simple, easy, and safe technique, worth clinical promotion.
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