In SituFabrication of Nanoprobes for 19F Magnetic Resonance andPhotoacoustic Imaging-Guided Tumor Therapy

It is challenging to fabricate multimodal imaging nanoprobes with highpenetration depth and long blood circulation. Herein, we present multifunctionalfluorinated nanoprobes (CFPP NPs) containingin situformed copper chalcogenidenanoparticles for19F magnetic resonance imaging (MRI) and photoacoustic imaging(PAI). The formed hydrophilic copper chalcogenide nanoassemblies demonstrated easyexcretion stemming from facile disassembly, enhanced photothermal ability, and novellocalized surface plasmon resonance (LSPR) absorption (centered at 1064 nm) in thebiological transparentregion. Both19F MRI and PAI render these CFPP NPs suitable formultimodal imaging with high penetration depth and low background. Moreover, thechemo-photothermal synergistic therapy results suggest great potential in multimodalnanoprobes for imaging-guided tumor therapy applications.

Automated summary

This paper presents multifunctional fluorinated nanoprobes for MRI and PAI. These nanoprobes have high penetration depth and low background, making them suitable for multimodal imaging. Furthermore, they show potential in chemo-photothermal synergistic therapy.