Journal
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Volume 414, Issue 16, Pages 4655-4666Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-022-04085-5
Keywords
Nanozyme; Oxidase-like; Peroxidase-like; Enzymatic cascade reaction; Glucose detection
Funding
- National Natural Science Foundation of China [21904043, 21575044]
- Natural Science Foundation of Fujian Province of China [2015J01054, 2016J01062]
- Foundation of Graphene Powder & Composite Research Center of Fujian Province [2017H2001]
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Researchers have developed a dual-functional catalytic nanozyme for efficient colorimetric analysis through the fabrication of a CuO/Au heterostructure dendrimer. This nanozyme showed selectivity, anti-interference ability, and reproducibility, and it could be used for glucose detection.
Multifunctional catalytic performance plays a crucial role in bio-applications through the diversity and durability of artificial nanozymes. An effective synergy with sufficient accessible active sites and high specific surface area is a challenge for composite catalysts, especially to avoid uncontrollable aggregation and structural instability. Here, we fabricated a CunO/Au heterostructure dendrimer on copper foam ( CunO/Au HD/CF) as dual functional catalytic nanozyme to achieve enzyme mimic cascade reactions for efficient colorimetric analysis. A highly porous CF skeleton-based CuO nanowire array (CuO NWA) with a large specific surface area supported an efficient load capacity to assemble sufficient CunO/Au HD by electrodeposition. The bimetallic Au-Cu nanozyme successfully achieved an oxidase-like and peroxidase-like cascade catalysis by a target-responsive sensing mechanism. Due to the confirmed catalytic performance of selectivity, anti-interference ability, and reproducibility, a CunO/Au HD/CF-based quantitative analytical method was developed for glucose detection with a wide linear range and considerable detection limit of 8.4 mu M. The robust nonenzymatic catalytic strategy for colorimetric detection not only confirmed the dual functional catalytic activity of CunO/Au HD/CF, but also showed great potential for applications in clinical diagnostics and biochemical analysis.
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