Journal
ANALYTICA CHIMICA ACTA
Volume 1211, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.aca.2022.339880
Keywords
Enantioselective HPLC; Chiralpak AD-3; Receptor-like enantioseparation; 2-Propanol; Planar chiral 1; 2-ferrocenes
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The study demonstrated an ON/OFF switching of receptor-like chiral discrimination through the use of different alcohols as mobile phases. The differences in retention times between the enantiomers of nine planar chiral 1,2-ferrocenes were significantly influenced by the choice of alcohol.
A set of nine planar chiral 1,2-ferrocenes was analyzed by high-performance liquid chromatography (HPLC) on the amylose tris(3,5-dimethylphenylcarbamate) chiral stationary phase. The enantioseparations were carried out using neat methanol, ethanol, 1-propanol, and 2-propanol as well as mixtures of n-hexane-2-propanol as mobile phases. The differences in retention times between the second eluted (Rp)-enantiomers and the first eluted (Sp)-enantiomers were significantly influenced by elution modes and the steric hindrance of substituents at the aromatic rings of the ferrocene backbone. It has been demonstrated an ON/OFF switching of receptor-like chiral discrimination through the employment of different alcohols as mobile phases. In particular, the presence of pure 2-propanol triggers exceptional conditions of enantioselectivity that for some ferrocenes result in values of the enantioseparation factor higher than 80.
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