4.7 Article

Aptamers from random sequence space: Accomplishments, gaps and future considerations

Related references

Note: Only part of the references are listed.
Article Chemistry, Analytical

Enzyme-free signal amplified Au nanoparticle fluorescence detection of thrombin via target-triggered catalytic hairpin assembly

Terefe Tafese Bezuneh et al.

Summary: An enzyme-free target-triggered catalytic hairpin assembly (CHA) was proposed for signal amplified fluorescence thrombin detection, demonstrating a limit of detection (LOD) of 165 pM and linear range from 0.2 to 100 nM. The method could be potentially applied in complex biological matrices for sensitive detection of thrombin.

MICROCHEMICAL JOURNAL (2021)

Review Chemistry, Multidisciplinary

2′-Fluoro-arabinonucleic Acid (FANA): A Versatile Tool for Probing Biomolecular Interactions

Roberto El-Khoury et al.

Summary: FANA is an ideal tool for mimicking DNA secondary structures and probing biomolecular interactions, showing high binding affinity and implications in therapeutics. It also holds promise in stabilizing noncanonical DNA structures and playing a role in biological research.

ACCOUNTS OF CHEMICAL RESEARCH (2021)

Article Multidisciplinary Sciences

Photophysics of DFHBI bound to RNA aptamer Baby Spinach

Nguyen Thuan Dao et al.

Summary: The study focused on Baby Spinach, a truncated version of the Spinach RNA aptamer, and found that its fluorescence and excitation spectra were similar to those of the full Spinach aptamer. The unexpected discrepancy between absorption and fluorescence excitation spectra in the DFHBI/RNA complex could be explained by competing dark and fluorescent binding sites. This abnormal absorption spectrum might be caused by trans-isomers formed within the cis-bound DFHBI/RNA complex, providing valuable insight into the efficiency of a fluorogenic dye/RNA system.

SCIENTIFIC REPORTS (2021)

Article Biochemistry & Molecular Biology

High-affinity five/six-letter DNA aptamers with superior specificity enabling the detection of dengue NS1 protein variants beyond the serotype identification

Ken-Ichiro Matsunaga et al.

Summary: Expanding the genetic alphabet of DNA with unnatural bases significantly enhances the affinity of DNA aptamers for target proteins, resulting in high-specificity UB-DNA aptamers; these high-affinity UB-DNA aptamers demonstrate remarkable target specificity, capable of identifying subtle variants of DEN-NS1 and enabling precise diagnoses of diseases.

NUCLEIC ACIDS RESEARCH (2021)

Article Biochemistry & Molecular Biology

Diverse high-affinity DNA aptamers for wild-type and B.1.1.7 SARS-CoV-2 spike proteins from a pre-structured DNA library

Jiuxing Li et al.

Summary: In vitro selection experiments identified DNA aptamers, MSA1 and MSA5, with strong binding affinity to the S1 subunit of the SARS-CoV-2 spike protein. These aptamers demonstrated comparable affinities for various forms of S1 protein and also recognized the pseudotyped lentivirus of SARS-CoV-2, highlighting their potential as diagnostic tools for COVID-19 detection. The development of a colorimetric sandwich assay using MSA1 further confirmed the utility of these aptamers in detecting the virus in saliva samples.

NUCLEIC ACIDS RESEARCH (2021)

Article Chemistry, Multidisciplinary

Theophylline-induced synergic activation of guide RNA to control CRISPR/Cas9 function

Yan Liu et al.

Summary: CRISPR/Cas9 function can be activated through ligand-induced approach by integrating the theophylline aptamer into protein-unrecognized regions of guide RNA. This allosteric regulation design offers a new perspective for the conditional control of CRISPR/Cas9 function through the involvement of RNA aptamers.

CHEMICAL COMMUNICATIONS (2021)

Article Biochemical Research Methods

APTANI2: update of aptamer selection through sequence-structure analysis

Jimmy Caroli et al.

BIOINFORMATICS (2020)

Article Plant Sciences

A Theophylline-Responsive Riboswitch Regulates Expression of Nuclear-Encoded Genes

Nana Shanidze et al.

PLANT PHYSIOLOGY (2020)

Article Chemistry, Multidisciplinary

Specific Binding of a d-RNA G-Quadruplex Structure with an l-RNA Aptamer

Chun-Yin Chan et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Review Biochemistry & Molecular Biology

Aptamer-Based Targeted Drug Delivery Systems: Current Potential and Challenges

Fen He et al.

CURRENT MEDICINAL CHEMISTRY (2020)

Article Chemistry, Multidisciplinary

Selection of Aptamers with Large Hydrophobic 2′-Substituents

Qian Shao et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

Article Chemistry, Multidisciplinary

In Vitro Selection of a DNA Aptamer Targeting Degraded Protein Fragments for Biosensing

Meng Liu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Article Biochemistry & Molecular Biology

In Vitro Selection of New DNA Aptamers for Human Vascular Endothelial Growth Factor 165

Sepehr Manochehry et al.

CHEMBIOCHEM (2020)

Article Multidisciplinary Sciences

In silico design and validation of high-affinity RNA aptamers targeting epithelial cellular adhesion molecule dimers

David R. Bell et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Biochemistry & Molecular Biology

RaptRanker: in silico RNA aptamer selection from HT-SELEX experiment based on local sequence and structure information

Ryoga Ishida et al.

NUCLEIC ACIDS RESEARCH (2020)

Review Biochemistry & Molecular Biology

Using Aptamers as a Novel Method for Determining GnRH/LH Pulsatility

Chioma Izzi-Engbeaya et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Biochemistry & Molecular Biology

Evolution of a highly functional circular DNA aptamer in serum

Yu Mao et al.

NUCLEIC ACIDS RESEARCH (2020)

Review Biochemistry & Molecular Biology

Methods and Applications of In Silico Aptamer Design and Modeling

Andrey A. Buglak et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Materials Science, Biomaterials

Genetically encoded light-up RNA aptamers and their applications for imaging and biosensing

Puchakayala Swetha et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

Review Biochemistry & Molecular Biology

Recent Advances in Aptamer Discovery and Applications

Yang Zhang et al.

MOLECULES (2019)

Article Chemistry, Multidisciplinary

In Vitro Selection of Circular DNA Aptamers for Biosensing Applications

Meng Liu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

Article Biochemistry & Molecular Biology

Next-level riboswitch development-implementation of Capture-SELEX facilitates identification of a new synthetic riboswitch

Adrien Boussebayle et al.

NUCLEIC ACIDS RESEARCH (2019)

Review Chemistry, Analytical

Aptamer and nanomaterial based FRET biosensors: a review on recent advances (2014-2019)

Zeki Semih Pehlivan et al.

MICROCHIMICA ACTA (2019)

Article Multidisciplinary Sciences

Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs

Kale Kundert et al.

NATURE COMMUNICATIONS (2019)

Article Chemistry, Multidisciplinary

Regulation of Protein Activity and Cellular Functions Mediated by Molecularly Evolved Nucleic Acids

Jie Tan et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

Article Medicine, Research & Experimental

The Discovery of RNA Aptamers that Selectively Bind Glioblastoma Stem Cells

Alessandra Affinito et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2019)

Article Chemistry, Multidisciplinary

Control of CRISPR-Cas9 with small molecule-activated allosteric aptamer regulating sgRNAs

Bingqian Lin et al.

CHEMICAL COMMUNICATIONS (2019)

Article Multidisciplinary Sciences

SIMS analyses of the oldest known assemblage of microfossils document their taxon-correlated carbon isotope compositions

J. William Schopf et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Agriculture, Multidisciplinary

Selection, Identification, and Binding Mechanism Studies of an ssDNA Aptamer Targeted to Different Stages of E-coli O157:H7

Ying Zou et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2018)

Article Biotechnology & Applied Microbiology

Whole-bacterium SELEX of DNA aptamers for rapid detection of E. coli O157:H7 using a QCM sensor

Xiaofan Yu et al.

JOURNAL OF BIOTECHNOLOGY (2018)

Article Chemistry, Analytical

ssDNA-tailorable oxidase-mimicking activity of spinel MnCo2O4 for sensitive biomolecular detection in food sample

Lunjie Huang et al.

SENSORS AND ACTUATORS B-CHEMICAL (2018)

Review Medicine, Research & Experimental

Aptamers in the Therapeutics and Diagnostics Pipelines

Harleen Kaur et al.

THERANOSTICS (2018)

Article Medicine, Research & Experimental

In Vivo SELEX of an Inhibitory NSCLC-Specific RNA Aptamer from PEGylated RNA Library

Hanlu Wang et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2018)

Article Medicine, Research & Experimental

An Aptamer-Based Probe for Molecular Subtyping of Breast Cancer

Mei Liu et al.

THERANOSTICS (2018)

Article Biochemistry & Molecular Biology

Live Cell Imaging of Endogenous mRNA Using RNA-Based Fluorescence Turn-On Probe

Wei Qiang Ong et al.

ACS CHEMICAL BIOLOGY (2017)

Review Biotechnology & Applied Microbiology

Aptamers as targeted therapeutics: current potential and challenges

Jiehua Zhou et al.

NATURE REVIEWS DRUG DISCOVERY (2017)

Review Biochemistry & Molecular Biology

Recent Advances in SELEX Technology and Aptamer Applications in Biomedicine

Zhenjian Zhuo et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Review Biochemistry & Molecular Biology

Chemical Modifications of Nucleic Acid Aptamers for Therapeutic Purposes

Shuaijian Ni et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Article Chemistry, Multidisciplinary

Circular Bivalent Aptamers Enable in Vivo Stability and Recognition

Hailan Kuai et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

Article Biochemical Research Methods

Selection of aptamers based on a protein microarray integrated with a microfluidic chip

Xiaohui Liu et al.

LAB ON A CHIP (2017)

Article Chemistry, Analytical

Selection and characterization of DNA aptamers against the steroid testosterone

Vasso Skouridou et al.

MICROCHIMICA ACTA (2017)

Article Chemistry, Multidisciplinary

Defining the copper binding aptamotif and aptamer integrated recovery platform (AIRP)

Simranjeet Singh Sekhon et al.

NANOSCALE (2017)

Article Chemistry, Organic

Whole cell-SELEX of aptamers with a tyrosine-like side chain against live bacteria

Marleen Renders et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2017)

Article Biochemistry & Molecular Biology

Riboswitch diversity and distribution

Phillip J. McCown et al.

Article Chemistry, Multidisciplinary

Analysis of aptamer discovery and technology

Matthew R. Dunn et al.

Nature Reviews Chemistry (2017)

Article Chemistry, Multidisciplinary

An Aptamer-based Colorimetric Sensor for Streptomycin and Its Application in Food Inspection

Liu Zhongcheng et al.

CHEMICAL RESEARCH IN CHINESE UNIVERSITIES (2017)

Article Biochemical Research Methods

DNA aptamer identification and characterization for E-coli O157 detection using cell based SELEX method

Masoum Amraee et al.

ANALYTICAL BIOCHEMISTRY (2017)

Review Chemistry, Multidisciplinary

Synthetic mimics of biotin/(strept)avidin

Wenqi Liu et al.

CHEMICAL SOCIETY REVIEWS (2017)

Article Biochemistry & Molecular Biology

Development of a DNA aptamer that binds specifically to group A Streptococcus serotype M3

Hanif Alfavian et al.

CANADIAN JOURNAL OF MICROBIOLOGY (2017)

Review Chemistry, Multidisciplinary

Advancements in Aptamer Discovery Technologies

Michael R. Gotrik et al.

ACCOUNTS OF CHEMICAL RESEARCH (2016)

Article Chemistry, Analytical

Aptamer Affinity Maturation by Resampling and Microarray Selection

Andrew B. Kinghorn et al.

ANALYTICAL CHEMISTRY (2016)

Article Biochemistry & Molecular Biology

Embracing proteins: structural themes in aptamer-protein complexes

Amy D. Gelinas et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2016)

Article Infectious Diseases

DNA aptamers for the detection of Haemophilus influenzae type b by cell SELEX

F. S. Bitaraf et al.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2016)

Article Oncology

3D Cell-SELEX: Development of RNA aptamers as molecular probes for PC-3 tumor cell line

Aline G. Souza et al.

EXPERIMENTAL CELL RESEARCH (2016)

Review Biochemistry & Molecular Biology

Multivalent Aptamers: Versatile Tools for Diagnostic and Therapeutic Applications

Mariya Vorobyeva et al.

MOLECULES (2016)

Article Biochemistry & Molecular Biology

iSpinach: a fluorogenic RNA aptamer optimized for in vitro applications

Alexis Autour et al.

NUCLEIC ACIDS RESEARCH (2016)

Article Biochemistry & Molecular Biology

Selection of a high-affinity and in vivo bioactive ssDNA aptamer against angiotensin II peptide

Mohammad Heiat et al.

PEPTIDES (2016)

Article Biochemistry & Molecular Biology

2′Fluoro Modification Differentially Modulates the Ability of RNAs to Activate Pattern Recognition Receptors

Youngju Lee et al.

NUCLEIC ACID THERAPEUTICS (2016)

Article Biochemistry & Molecular Biology

AptaTRACE Elucidates RNA Sequence-Structure Motifs from Selection Trends in HT-SELEX Experiments

Phuong Dao et al.

CELL SYSTEMS (2016)

Article Chemistry, Analytical

Comprehensive Analytical Comparison of Strategies Used for Small Molecule Aptamer Evaluation

Maureen McKeague et al.

ANALYTICAL CHEMISTRY (2015)

Article Chemistry, Multidisciplinary

A Versatile Approach Towards Nucleobase-Modified Aptamers

Fabian Tolle et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)

Review Biochemistry & Molecular Biology

DNA Aptamers in the Diagnosis and Treatment of Human Diseases

Qinchang Zhu et al.

MOLECULES (2015)

Article Multidisciplinary Sciences

The isolation of an RNA aptamer targeting to p53 protein with single amino acid mutation

Liang Chen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Multidisciplinary Sciences

Imaging metabolite dynamics in living cells using a Spinach-based riboswitch

Mingxu You et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Medicine, Research & Experimental

Aptamer Selection Technology and Recent Advances

Michael Blind et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2015)

Article Chemistry, Analytical

Array-based Discovery of Aptamer Pairs

Minseon Cho et al.

ANALYTICAL CHEMISTRY (2015)

Review Chemistry, Analytical

Aptamer-based biosensors for biomedical diagnostics

Wenhu Zhou et al.

ANALYST (2014)

Article Engineering, Biomedical

Inhibition of human neutrophil activity by an RNA aptamer bound to interleukin-8

Ho Jin Sung et al.

BIOMATERIALS (2014)

Article Biochemical Research Methods

Microfluidic approaches to rapid and efficient aptamer selection

Hui Lin et al.

BIOMICROFLUIDICS (2014)

Article Biophysics

Evolution of Specificity in Protein-Protein Interactions

Orit Peleg et al.

BIOPHYSICAL JOURNAL (2014)

Article Biochemical Research Methods

Systematic selection of modified aptamer pairs for diagnostic sandwich assays

Urs A. Ochsner et al.

BIOTECHNIQUES (2014)

Review Biochemistry & Molecular Biology

The Expanding View of RNA and DNA Function

Ronald R. Breaker et al.

CHEMISTRY & BIOLOGY (2014)

Article Biochemistry & Molecular Biology

In Vitro Selection of a Single-Stranded DNA Molecular Recognition Element against Atrazine

Ryan M. Williams et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2014)

Article Biochemical Research Methods

Proteomics Analysis of Cancer Exosomes Using a Novel Modified Aptamer-based Array (SOMAscanTM) Platform*

Jason Webber et al.

MOLECULAR & CELLULAR PROTEOMICS (2014)

Article Biochemistry & Molecular Biology

Structural basis for activity of highly efficient RNA mimics of green fluorescent protein

Katherine Deigan Warner et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2014)

Article Multidisciplinary Sciences

In vitro selection with artificial expanded genetic information systems

Kwame Sefah et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Medicine, Research & Experimental

Nucleic Acid Ligands With Protein-like Side Chains: Modified Aptamers and Their Use as Diagnostic and Therapeutic Agents

John C. Rohloff et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2014)

Article Microbiology

BLIP-II Is a Highly Potent Inhibitor of Klebsiella pneumoniae Carbapenemase (KPC-2)

Nicholas G. Brown et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2013)

Review Biotechnology & Applied Microbiology

Streptavidin-biotin technology: improvements and innovations in chemical and biological applications

Christopher M. Dundas et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2013)

Article Infectious Diseases

Detection of Clostridium difficile toxins A, B and binary toxin with slow off-rate modified aptamers

Urs A. Ochsner et al.

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE (2013)

Review Pharmacology & Pharmacy

Therapeutic RNA aptamers in clinical trials

Padma Sundaram et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2013)

Article Biotechnology & Applied Microbiology

Generation of high-affinity DNA aptamers using an expanded genetic alphabet

Michiko Kimoto et al.

NATURE BIOTECHNOLOGY (2013)

Article Multidisciplinary Sciences

RAPID-SELEX for RNA Aptamers

Kylan Szeto et al.

PLOS ONE (2013)

Article Biochemistry & Molecular Biology

In Vitro Selection of Modified RNA Aptamers Against CD44 Cancer Stem Cell Marker

Nidaa Ababneh et al.

NUCLEIC ACID THERAPEUTICS (2013)

Article Chemistry, Multidisciplinary

Peptide nucleic acids are an additional class of aptamers

Eun Jeong Lee et al.

RSC ADVANCES (2013)

Article Medicine, Research & Experimental

In vivo SELEX for Identification of Brain-penetrating Aptamers

Congsheng Cheng et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2013)

Review Biochemistry & Molecular Biology

Aptamers: Problems, Solutions and Prospects

A. V. Lakhin et al.

ACTA NATURAE (2013)

Article Chemistry, Analytical

DNase-Mediated Single-Cycle Selection of Aptamers for Proteins Blotted on a Membrane

Yanming Liu et al.

ANALYTICAL CHEMISTRY (2012)

Article Chemistry, Analytical

Impedimetric DNA Aptasensor for Sensitive Detection of Ochratoxin A in Food

Gabriela Castillo et al.

ELECTROANALYSIS (2012)

Article Biotechnology & Applied Microbiology

Isolation and Optimization of Murine IL-10 Receptor Blocking Oligonucleotide Aptamers Using High-throughput Sequencing

Alexey Berezhnoy et al.

MOLECULAR THERAPY (2012)

Article Multidisciplinary Sciences

Fluoride ion encapsulation by Mg2+ ions and phosphates in a fluoride riboswitch

Aiming Ren et al.

NATURE (2012)

Article Biochemical Research Methods

Advances in human proteomics at high scale with the SOMAscan proteomics platform

Larry Gold et al.

NEW BIOTECHNOLOGY (2012)

Article Biochemistry & Molecular Biology

Highly specific unnatural base pair systems as a third base pair for PCR amplification

Rie Yamashige et al.

NUCLEIC ACIDS RESEARCH (2012)

Article Biochemistry & Molecular Biology

Selection is more intelligent than design: improving the affinity of a bivalent ligand through directed evolution

Kareem M. Ahmad et al.

NUCLEIC ACIDS RESEARCH (2012)

Article Multidisciplinary Sciences

Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets

Douglas R. Davies et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Chemistry, Multidisciplinary

Evolution and Protein Packaging of Small-Molecule RNA Aptamers

Jolene L. Lau et al.

ACS NANO (2011)

Article Biochemistry & Molecular Biology

How the biotin-streptavidin interaction was made even stronger: investigation via crystallography and a chimaeric tetramer

Claire E. Chivers et al.

BIOCHEMICAL JOURNAL (2011)

Article Biochemistry & Molecular Biology

Engineered Streptavidin Monomer and Dimer with Improved Stability and Function

Kok Hong Lim et al.

BIOCHEMISTRY (2011)

Article Biochemical Research Methods

Aptamer selection by high-throughput sequencing and informatic analysis

Shawn Hoon et al.

BIOTECHNIQUES (2011)

Article Oncology

Metastasis-focused cell-based SELEX generates aptamers inhibiting cell migration and invasion

Elina Zueva et al.

INTERNATIONAL JOURNAL OF CANCER (2011)

Article Biochemistry & Molecular Biology

Bi-specific Aptamers Mediating Tumor Cell Lysis

Achim Boltz et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

Development of Single-Stranded DNA Aptamers for Specific Bisphenol A Detection

Minjoung Jo et al.

OLIGONUCLEOTIDES (2011)

Article Multidisciplinary Sciences

Probing the Limits of Aptamer Affinity with a Microfluidic SELEX Platform

Kareem M. Ahmad et al.

PLOS ONE (2011)

Article Multidisciplinary Sciences

Evolution of functional nucleic acids in the presence of nonheritable backbone heterogeneity

Simon G. Trevino et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Multidisciplinary Sciences

RNA Mimics of Green Fluorescent Protein

Jeremy S. Paige et al.

SCIENCE (2011)

Article Biochemistry & Molecular Biology

The Structure of a Tetrahydrofolate-Sensing Riboswitch Reveals Two Ligand Binding Sites in a Single Aptamer

Jeremiah J. Trausch et al.

STRUCTURE (2011)

Review Chemistry, Multidisciplinary

Aptamers Generated from Cell-SELEX for Molecular Medicine: A Chemical Biology Approach

Xiaohong Fang et al.

ACCOUNTS OF CHEMICAL RESEARCH (2010)

Article Chemistry, Multidisciplinary

Specific Colorimetric Detection of Proteins Using Bidentate Aptamer-Conjugated Polydiacetylene (PDA) Liposomes

Yun Kyung Jung et al.

ADVANCED FUNCTIONAL MATERIALS (2010)

Article Biochemical Research Methods

An aptamer-based fluorescent biosensor for potassium ion detection using a pyrene-labeled molecular beacon

Chao Shi et al.

ANALYTICAL BIOCHEMISTRY (2010)

Article Chemistry, Analytical

Development of an Aptamer Beacon for Detection of Interferon-Gamma

Nazgul Tuleuova et al.

ANALYTICAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

Ribozymes and Riboswitches: Modulation of RNA Function by Small Molecules

Jinwei Zhang et al.

BIOCHEMISTRY (2010)

Article Biochemistry & Molecular Biology

An RNA Aptamer That Selectively Inhibits the Enzymatic Activity of Protein Tyrosine Phosphatase 1B in vitro

Brent Townshend et al.

CHEMBIOCHEM (2010)

Article Chemistry, Analytical

Label-Free Electrochemical Thrombin Aptasensor Based on Ag Nanoparticles Modified Electrode

Elena Suprun et al.

ELECTROANALYSIS (2010)

Article Chemistry, Multidisciplinary

Enhanced Functional Potential of Nucleic Acid Aptamer Libraries Patterned to Increase Secondary Structure

Karen M. Ruff et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)

Article Biochemistry & Molecular Biology

Selection and Characterization of DNA Aptamers for Egg White Lysozyme

Dinh T. Tran et al.

MOLECULES (2010)

Article Biochemistry & Molecular Biology

In vivo selection of tumor-targeting RNA motifs

Jing Mi et al.

NATURE CHEMICAL BIOLOGY (2010)

Article Biochemistry & Molecular Biology

Selection of DNA aptamers using atomic force microscopy

Yusuke Miyachi et al.

NUCLEIC ACIDS RESEARCH (2010)

Review Astronomy & Astrophysics

The chemical biology of methanogenesis

James G. Ferry

PLANETARY AND SPACE SCIENCE (2010)

Article Multidisciplinary Sciences

Aptamer-Based Multiplexed Proteomic Technology for Biomarker Discovery

Larry Gold et al.

PLOS ONE (2010)

Article Multidisciplinary Sciences

Quantitative selection of DNA aptamers through microfluidic selection and high-throughput sequencing

Minseon Cho et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Review Biotechnology & Applied Microbiology

Targeting cancer cells with nucleic acid aptamers

Laura Cerchia et al.

TRENDS IN BIOTECHNOLOGY (2010)

Article Chemistry, Analytical

Generation of Highly Specific Aptamers via Micromagnetic Selection

Jiangrong Qian et al.

ANALYTICAL CHEMISTRY (2009)

Review Biochemistry & Molecular Biology

The Structural and Functional Diversity of Metabolite-Binding Riboswitches

Adam Roth et al.

ANNUAL REVIEW OF BIOCHEMISTRY (2009)

Article Biochemistry & Molecular Biology

RNA aptamer binding to polyhistidine-tag

Shoutaro Tsuji et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)

Review Chemistry, Medicinal

Aptamers: from bench side research towards patented molecules with therapeutic applications

Paromita Majumder et al.

EXPERT OPINION ON THERAPEUTIC PATENTS (2009)

Review Chemistry, Medicinal

Aptamers as inhibitors of target proteins

S. Missailidis et al.

EXPERT OPINION ON THERAPEUTIC PATENTS (2009)

Article Chemistry, Multidisciplinary

Conditional RNA Interference Mediated by Allosteric Ribozyme

Deepak Kumar et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)

Article Chemistry, Organic

New theophylline-activated Diels-Alderase ribozymes by molecular engineering

Markus Petermeier et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2009)

Article Multidisciplinary Sciences

Micromagnetic selection of aptamers in microfluidic channels

Xinhui Lou et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Agriculture, Multidisciplinary

Determination of Ochratoxin A with a DNA Aptamer

Jorge A. Cruz-Aguado et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2008)

Article Chemistry, Multidisciplinary

Engineering Complex Riboswitch Regulation by Dual Genetic Selection

Vandana Sharma et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)

Article Biochemistry & Molecular Biology

Model-guided design of ligand-regulated RNAi for programmable control of gene expression

Chase L. Beisel et al.

MOLECULAR SYSTEMS BIOLOGY (2008)

Article Multidisciplinary Sciences

Structural insights into amino acid binding and gene control by a lysine riboswitch

Alexander Serganov et al.

NATURE (2008)

Review Biochemical Research Methods

Biotinylation reagents for the study of cell surface proteins

Giuliano Elia

PROTEOMICS (2008)

Article Biochemistry & Molecular Biology

Crystal structure of an RNA aptamer bound to thrombin

Stephen B. Long et al.

Article Chemistry, Analytical

Improvement of aptamer affinity by dimerization

Hijiri Hasegawa et al.

SENSORS (2008)

Article Biochemistry & Molecular Biology

Multidomain targeting generates a high-affinity thrombin-inhibiting bivalent aptamer

Jens Mueller et al.

CHEMBIOCHEM (2007)

Article Biochemistry & Molecular Biology

Elucidation of the RNA target of linezolid by using a linezolid-neomycin B heteroconjugate and genomic SELEX

Hyun Jin Kim et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2007)

Article Chemistry, Analytical

Selection of aptamers for molecular recognition and characterization of cancer cells

Zhiwen Tang et al.

ANALYTICAL CHEMISTRY (2007)

Article Multidisciplinary Sciences

Specificity in protein interactions and its relationship with sequence diversity and coevolution

Luke Hakes et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Review Biochemistry & Molecular Biology

Unnatural base pair systems for DNA/RNA-based biotechnology

Ichiro Hirao

CURRENT OPINION IN CHEMICAL BIOLOGY (2006)

Article Multidisciplinary Sciences

Aptamers evolved from live cells as effective molecular probes for cancer study

Dihua Shangguan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Review Biotechnology & Applied Microbiology

Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease

EWM Ng et al.

NATURE REVIEWS DRUG DISCOVERY (2006)

Article Biochemistry & Molecular Biology

Comparison of different strategies to select aptamers against a transmembrane protein target

Carine Pestourie et al.

OLIGONUCLEOTIDES (2006)

Article Biochemistry & Molecular Biology

In vitro selection of DNA aptamers binding ethanolamine

D Mann et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)

Article Biochemistry & Molecular Biology

Size, constant sequences, and optimal selection

M Legiewicz et al.

Article Biochemistry & Molecular Biology

The kinetics of ligand binding by an adenine-sensing riboswitch

JK Wickiser et al.

BIOCHEMISTRY (2005)

Article Biochemistry & Molecular Biology

Deconvolution of a complex target using DNA aptamers

S Fitter et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Biochemical Research Methods

Selection of RNA aptamers against human influenza virus hemagglutinin using surface plasmon resonance

TS Misono et al.

ANALYTICAL BIOCHEMISTRY (2005)

Article Biochemistry & Molecular Biology

The speed of RNA transcription and metabolite binding kinetics operate an FMN riboswitch

JK Wickiser et al.

MOLECULAR CELL (2005)

Article Biochemistry & Molecular Biology

Direct in vitro selection of a 2 '-O-methyl aptamer to VEGF

PE Burmeister et al.

CHEMISTRY & BIOLOGY (2005)

Article Multidisciplinary Sciences

New RNA motifs suggest an expanded scope for riboswitches in bacterial genetic control

JE Barrick et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Multidisciplinary Sciences

Control of gene expression by a natural metabolite-responsive ribozyme

WC Winkler et al.

NATURE (2004)

Article Biochemistry & Molecular Biology

Sialyllactose-binding modified DNA aptamer bearing additional functionality by SELEX

MM Masud et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2004)

Article Chemistry, Multidisciplinary

Dissecting the cholera toxin-ganglioside GM1 interaction by isothermal titration calorimetry

WB Turnbull et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)

Article Biochemistry & Molecular Biology

A theophylline responsive riboswitch based on helix slipping controls gene expression in vivo

B Suess et al.

NUCLEIC ACIDS RESEARCH (2004)

Article Chemistry, Multidisciplinary

In vitro evolution of functional DNA using capillary electrophoresis

SD Mendonsa et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)

Article Biochemistry & Molecular Biology

Adenine riboswitches and gene activation by disruption of a transcription terminator

M Mandal et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2004)

Article Biochemistry & Molecular Biology

Coenzyme B-12 riboswitches are widespread genetic control elements in prokaryotes

A Nahvi et al.

NUCLEIC ACIDS RESEARCH (2004)

Article Biochemistry & Molecular Biology

An mRNA structure that controls gene expression by binding S-adenosylmethionine

WC Winkler et al.

NATURE STRUCTURAL BIOLOGY (2003)

Article Biochemistry & Molecular Biology

Encapsulating streptomycin within a small 40-mer RNA

V Tereshko et al.

CHEMISTRY & BIOLOGY (2003)

Review Biotechnology & Applied Microbiology

LNA: a versatile tool for therapeutics and genomics

M Petersen et al.

TRENDS IN BIOTECHNOLOGY (2003)

Article Cell Biology

An mRNA structure in bacteria that controls gene expression by binding lysine

N Sudarsan et al.

GENES & DEVELOPMENT (2003)

Article Multidisciplinary Sciences

An mRNA structure that controls gene expression by binding FMN

WC Winkler et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Biochemistry & Molecular Biology

Sensing small molecules by nascent RNA: A mechanism to control transcription in bacteria

AS Mironov et al.

Article Multidisciplinary Sciences

Isolation of high-affinity GTP aptamers from partially structured RNA libraries

JH Davis et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Biochemistry & Molecular Biology

In vitro selection of RNA aptamers that bind to cell adhesion receptors of Trypanosoma cruzi and inhibit cell invasion

H Ulrich et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Biotechnology & Applied Microbiology

Generation of species cross-reactive aptamers using toggle SELEX

R White et al.

MOLECULAR THERAPY (2001)

Article Biochemistry & Molecular Biology

In vitro selection of DNA aptamers which bind to cholic acid

T Kato et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION (2000)

Article Biochemistry & Molecular Biology

2.8 Å crystal structure of the malachite green aptamer

C Baugh et al.

JOURNAL OF MOLECULAR BIOLOGY (2000)

Article Biochemistry & Molecular Biology

Towards the selection of phosphorothioate aptamers -: Optimizing in vitro selection steps with phosphorothioate nucleotides

ML Andreola et al.

EUROPEAN JOURNAL OF BIOCHEMISTRY (2000)

Article Biochemistry & Molecular Biology

Design and optimization of effector-activated ribozyme ligases

Michael P. Robertson et al.

NUCLEIC ACIDS RESEARCH (2000)

Review Multidisciplinary Sciences

Biochemistry - Adaptive recognition by nucleic acid aptamers

T Hermann et al.

SCIENCE (2000)