A highly branched macrocycle-based dual-channel sensor: Bodipy and pillar[5]arene combination for detection of Sn (II) &Hg (II) and bioimaging in living cells

A highly branched pillar[5]arene-based sensor containing multiple BODIPY units has been designed and synthesized (B-P[5]arene). Systematical experiments on metal ion detection of B-P[5]arene in aceto-nitrile/water by emission and absorption spectra indicate that this macrocycle shows high sensitivity and selectivity to both Sn (II) and Hg(II) by dual-channels. Hg (II) ions quenched to the fluorescence intensity of B-P[5]arene, while Sn (II) caused a broader spectrum without any shifting in wavelength. The detection limits of B-P[5]arene for Hg (II) and Sn (II) were found to be 1.09 x 10(-6) M and 3.18 x 10(-7) M, respectively. For two complex interactions, the metal ion: ligand ratio was determined as 1:2. The complex interactions between the Hg (II)&Sn(II) metal ions and B-P[5]arene are generally stable in both basic and acidic media due to strong interaction. (c) 2022 Elsevier B.V. All rights reserved.

Automated summary

A highly branched pillar[5]arene-based sensor (B-P[5]arene) containing multiple BODIPY units has been designed and synthesized. Systematical experiments show that B-P[5]arene exhibits high sensitivity and selectivity to both Sn (II) and Hg (II) in acetonitrile/water. Hg (II) ions quench the fluorescence intensity of B-P[5]arene, while Sn (II) causes a broader spectrum without any shifting in wavelength.