4.6 Article

Reported cases of end-stage kidney disease-United States, 2000-2019

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Article Urology & Nephrology

Kidney, Cardiovascular, and Safety Outcomes of Canagliflozin according to Baseline Albuminuria A CREDENCE Secondary Analysis

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Summary: Canagliflozin can safely reduce kidney and cardiovascular events in patients with type 2 diabetes and severely increased urine albumin-to-creatinine ratio (UACR). In this population, the relative kidney benefits remain consistent across different levels of albuminuria, with the greatest absolute kidney benefit observed in those with an UACR >= 3000 mg/g.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2021)