Journal
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
Volume 322, Issue 4, Pages C762-C768Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpcell.00022.2022
Keywords
ECM; epigenetics; fibrous; TME; therapy
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Funding
- National Institutes of Health [R03CA230815, R03CA248913, R01CA233481-01A1]
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This mini review discusses epigenetic modifications that regulate the expression of fibrous ECM proteins and glycoproteins and explores the prospects of targeting them for cancer therapy.
The tumor microenvironment (TME) composed of different types of cells embedded in extracellular matrix (ECM) has crucial effects on cancer growth and metastasis. ECM is made of a variety of proteins that provide structural support to the cells and regulate biological functions by modulating the cross talk among cells, thus effecting tumor growth and progression. In this mini review, the author discusses epigenetic modifications that regulate the expression of fibrous ECM proteins and glycoproteins and the prospects of targeting them for cancer therapy.
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