Journal
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
Volume 56, Issue 3, Pages 519-528Publisher
WILEY
DOI: 10.1111/apt.17052
Keywords
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Funding
- Gilead Sciences [IN-KR-988-5789, IN-US-20-10959]
- National Cancer Center [HA21C0110]
- Patient Centered Clinical Research Coordinating Center [HC20C0062]
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Simplifying and expanding treatment eligibility for chronic hepatitis B (CHB) in Korea can reduce the incidence of hepatocellular carcinoma (HCC) and save more lives. This measure, combined with high diagnostic rates, is highly cost-effective.
Background Antiviral treatment in patients with chronic hepatitis B (CHB) may decrease the risk of hepatocellular carcinoma (HCC) and death. However, only 2.2% of CHB patients receive antiviral treatment globally. The complexity and strictness of the current clinical practice guidelines may limit expanding the treatment coverage for CHB. Aims We examined the impact of expanding treatment criteria on future disease burden in Korea, a hepatitis B virus (HBV) endemic country with high diagnostic rates (74.2%). Materials Dynamic country-level data were used to estimate the HCC incidence, overall mortality and economic impact of three incremental scenarios compared to the base case in Korea through 2035. Results In 2020, 1,409,000 CHB cases were estimated, with the majority born before 1995. All scenarios assumed treating 70% of eligible individuals. The first scenario removes viral load restrictions in cirrhotic patients, which would avert 13,000 cases of HCC and save 11,800 lives. The second scenario, lowering the alanine aminotransferase (ALT) level restriction to the upper limit of the normal in non-cirrhotic patients, would avert 26,700 cases of HCC and save 23,300 lives. The last scenario removes the restriction by ALT and HBeAg in treating non-cirrhotic individuals with a viral load of >= 2000 IU/ml, which would avert 43,300 cases of HCC and save 37,000 lives. All scenarios were highly cost-effective. Conclusions Simplifying and expanding treatment eligibility for CHB would save many lives and be highly cost-effective when combined with high diagnostic rates. These dynamic country-level data may provide new insights for their global application.
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