Journal
AIDS RESEARCH AND HUMAN RETROVIRUSES
Volume 38, Issue 6, Pages 451-454Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/aid.2021.0202
Keywords
dual therapy; two-drug regimen; antiretroviral therapy; HIV; regimen simplification
Categories
Funding
- National Institute of Allergy and Infectious Diseases (NIAID) [5UM1AI06950314, 1R24AI152598-01]
- DC Center for AIDS Research, a National Institute of Health (NIH) [P30AI117970]
- NIAID
- National Cancer Institute
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- National Heart, Lung and Blood Institute
- National Institute on Drug Abuse
- National Institute of Mental Health
- National Institute on Aging
- Fogarty International Center
- National Institute of General Medical Sciences
- National Institute of Diabetes and Digestive and Kidney Diseases
- Office of AIDS Research
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This study investigated the virological outcomes of two-drug and three-drug antiretroviral regimens in adults with HIV. The results showed that adults receiving two-drug regimens had a slightly higher risk of virological failure at 24 months compared to those on three-drug regimens.
This study explored virological outcomes of two-drug (2DRs) and three-drug (3DRs) antiretroviral regimens in adults with HIV in the DC Cohort. We analyzed 310 treatment-experienced adults with sustained HIV RNA <= 50 copies/mL at baseline, 53 of whom switched to 2DRs and 257 continued 3DRs. Adults on 2DRs and 3DRs had similar demographics (median age 53.3 years, 76.8% cisgender male, 76.1% Black). Adults on 2DRs had more participants with >= 2 comorbidities (62.3% vs. 42.8%, p = .019), had a longer time since HIV diagnosis (median years 20.4 vs. 13.2, p = .017), and received the regimen of interest for a shorter duration (median years 1.3 vs. 3.3, p < .001) compared with adults on 3DRs. Adults receiving 2DRs had a higher, although nonsignificant, risk for virological failure (two consecutive HIV RNA >= 50 copies/mL) at 24 months follow-up than adults on 3DRs (6.7% vs. 1.7%, respectively; p = .10). Future analysis of the effectiveness of 2DRs is needed.
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