Journal
AGING-US
Volume 14, Issue 5, Pages 2287-2303Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/aging.203938
Keywords
MafK; Salmonella; colitis; apoptosis
Categories
Funding
- National Natural Science Foundation of China [81471028, 31902224]
- Jilin Scientific and Technological Development Program [20160101068JC]
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The overexpression of MafK increases susceptibility to Salmonella infection and exacerbates the disease by promoting epithelial cell apoptosis, leading to bacterial dissemination and inflammation.
Gastrointestinal homeostasis is critical for maintaining host health, and is affected by many factors. A recent report showed that Musculoaponeurotic fibrosarcoma K (MafK) expression is increased in patients that have ulcerative colitis (UC). Even so, MafK's significance in sustaining intestinal homeostasis has not been investigated. In this research, MafK overexpressing transgenic (MafK Tg) mice were found to be more susceptible to infection with Salmonella on the mucosa than the wild-type (WT) mice. Following Salmonella oral infection, MafK Tg mice suffered higher mortality and a lot more weight loss, damage to the intestines, and inflammation in the intestines than WT mice. MafK Tg mice were also unable to control Salmonella colonization and dissemination. In vivo data showed that increased MafK expression promoted epithelial cell apoptosis which was further confirmed by in vitro data. The rapid cleavage of caspase-3 in epithelial cells contributed to Salmonella dissemination and inflammation initiation. This study reveals that MafK participates in Salmonella pathogenesis acceleration by increasing caspase-3 activation.
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