Exploring aging interventions in human brain organoids

Review Cell Biology

Cellular senescence in ageing: from mechanisms to therapeutic opportunities

Raffaella Di Micco et al.

Summary: Cellular senescence is characterized by permanent proliferation arrest and can occur in response to various stresses like telomere dysfunction. Apart from stress-induced senescence, it can also be part of controlled programs in biological processes like embryonic development. Senescent cells contribute to impaired tissue regeneration, chronic diseases, and organismal aging, but also present an opportunity for intervention in aging and associated diseases.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

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Review Cell Biology

Cellular aging beyond cellular senescence: Markers of senescence prior to cell cycle arrest in vitro and in vivo

Mikolaj Ogrodnik

Summary: The field of cellular senescence research has expanded rapidly from in vitro studies of aging to animal and clinical research, focusing on the role of senescence markers in aging, disease, and anti-senescence interventions. The presence and role of these markers in cells prior to cell cycle arrest, particularly in replicative aging and in vivo conditions, are discussed. The article also explores disparities in quantifications of senescence markers in vivo and the applicational value of broadening the cellular senescence paradigm.

AGING CELL (2021)

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Article Cell Biology

Inhibition of the cGAS-STING pathway ameliorates the premature senescence hallmarks of Ataxia-Telangiectasia brain organoids

Julio Aguado et al.

Summary: Ataxia-telangiectasia (A-T) is a genetic disorder caused by the lack of functional ATM kinase, leading to chronic inflammation and premature aging in the central nervous system. The cGAS-STING pathway is shown to play a crucial role in recognizing micronuclei and inducing senescence-associated secretory phenotype (SASP) in A-T cells and brain organoids, making it a novel therapeutic target for treating neuropathology in A-T patients.

AGING CELL (2021)

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Article Neurosciences