4.7 Article

Non-enzymatic function of WRN RECQL helicase regulates removal of topoisomerase-I-DNA covalent complexes and triggers NF-κB signaling in cancer

Related references

Note: Only part of the references are listed.
Article Pharmacology & Pharmacy

Pharmacological targeting of differential DNA repair, radio-sensitizes WRN-deficient cancer cells in vitro and in vivo

Pooja Gupta et al.

Summary: The study demonstrated that pharmacological inhibition of CHK1 in WRN-deficient cancer cells leads to hyper-radiosensitization through modulation of homologous recombination repair, suggesting a potential therapeutic strategy for enhancing the efficacy of radiation treatment in WRN-deficient tumors.

BIOCHEMICAL PHARMACOLOGY (2021)

Article Pharmacology & Pharmacy

NF-κB inhibitors in treatment and prevention of lung cancer

Rajan Radha Rasmi et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

Article Biochemistry & Molecular Biology

APE2 promotes DNA damage response pathway from a single-strand break

Yunfeng Lin et al.

NUCLEIC ACIDS RESEARCH (2018)

Article Biochemistry & Molecular Biology

Poly(ADP-ribose) polymers regulate DNA topoisomerase I (Top1) nuclear dynamics and camptothecin sensitivity in living cells

Subhendu K. Das et al.

NUCLEIC ACIDS RESEARCH (2016)

Article Multidisciplinary Sciences

CDK1 phosphorylates WRN at collapsed replication forks

Valentina Palermo et al.

NATURE COMMUNICATIONS (2016)

Article Multidisciplinary Sciences

WRN regulates pathway choice between classical and alternative non-homologous end joining

Raghavendra A. Shamanna et al.

Nature Communications (2016)

Article Biochemistry & Molecular Biology

The WRN exonuclease domain protects nascent strands from pathological MRE11/EXO1-dependent degradation

Chiara Iannascoli et al.

NUCLEIC ACIDS RESEARCH (2015)

Review Biochemistry & Molecular Biology

Topoisomerase degradation, DSB repair, p53 and IAPs in cancer cell resistance to camptothecin-like topoisomerase I inhibitors

Maja T. Tomicic et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2013)

Review Biotechnology & Applied Microbiology

Tumor-specific microsatellite instability: Do distinct mechanisms underlie the MSI-L and EMAST phenotypes?

Suzanne E. Hile et al.

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2013)

Article Biochemistry & Molecular Biology

Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition

Matteo Berti et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2013)

Article Biochemistry & Molecular Biology

A rapid and sensitive assay for DNA-protein covalent complexes in living cells

Kostantin Kiianitsa et al.

NUCLEIC ACIDS RESEARCH (2013)

Review Multidisciplinary Sciences

Spectrum and Risk of Neoplasia in Werner Syndrome: A Systematic Review

Julia M. Lauper et al.

PLOS ONE (2013)

Article Multidisciplinary Sciences

APE2 is required for ATR-Chk1 checkpoint activation in response to oxidative stress

Jeremy Willis et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Biochemistry & Molecular Biology

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

Jianjiong Gao et al.

SCIENCE SIGNALING (2013)

Article Biochemistry & Molecular Biology

Topoisomerase I poisoning results in PARP-mediated replication fork reversal

Arnab Ray Chaudhuri et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2012)

Article Biochemistry & Molecular Biology

NF-κB regulates DNA double-strand break repair in conjunction with BRCA1-CtIP complexes

Meta Volcic et al.

NUCLEIC ACIDS RESEARCH (2012)

Review Genetics & Heredity

The xeroderma pigmentosum pathway: Decision tree analysis of DNA quality

Hanspeter Naegeli et al.

DNA REPAIR (2011)

Article Biochemistry & Molecular Biology

DNA Repair Factor MRE11/RAD50 Cleaves 3′-Phosphotyrosyl Bonds and Resects DNA to Repair Damage Caused by Topoisomerase 1 Poisons

Elizabeth J. Sacho et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

p50 (NF-κB1) Is an Effector Protein in the Cytotoxic Response to DNA Methylation Damage

Adam M. Schmitt et al.

MOLECULAR CELL (2011)

Article Biochemistry & Molecular Biology

A Nuclear Poly(ADP-Ribose)-Dependent Signalosome Confers DNA Damage-Induced IκB Kinase Activation

Michael Stilmann et al.

MOLECULAR CELL (2009)

Review Biochemistry & Molecular Biology

Shared principles in NF-κB signaling

Matthew S. Hayden et al.

Article Genetics & Heredity

WRN protects against topo I but not topo II inhibitors by preventing DNA break formation

Markus Christmann et al.

DNA REPAIR (2008)

Article Biochemistry & Molecular Biology

A ubiquitin-proteasome pathway for the repair of topoisomerase I-DNA covalent complexes

Chao-Po Lin et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Review Biochemistry & Molecular Biology

Rising from the RecQ-age: the role of human RecQ helicases in genome maintenance

Vilhelm A. Bohr

TRENDS IN BIOCHEMICAL SCIENCES (2008)

Article Multidisciplinary Sciences

Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer

Ruben Agrelo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Biochemistry & Molecular Biology

WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing

JJP Perry et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2006)