Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 364, Issue 13, Pages 2254-2259Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.202200305
Keywords
3-Aminofurans; 3-aminothiophenes; Alkynenitriles; Thorpe-Ziegler cyclization; conjugate addition
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Funding
- CSIR, New Delhi
- DST-SERB, New Delhi, India
- IIT Ropar
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An atom-economical approach for the synthesis of 3-aminofurans/thiophenes via conjugate addition and modified Thorpe-Ziegler cyclization has been reported. This operationally simple method offers a rapid access to a diverse library of compounds.
An atom-economical approach for the synthesis of 3-aminofurans/thiophenes via a conjugate addition of alcohols and thiols with electron withdrawing groups (EWGs) at alpha positions on alkynenitriles followed by a modified Thorpe-Ziegler cyclization have been reported. This operationally simple protocol offers a rapid access to a library of 3-aminofurans/thiophenes in moderate to good yields.
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