Substrate-Induced Synthesis of Coumarin-Fused Quinolinones from Anilines, 4-Hydroxycoumarins and DMSO under Air

Substrate-induced synthesis of 6H-Chromeno[4,3-b]quinolin-6-ones has been developed directly from anilines, 4-hydroxycoumarins and DMSO under air without any catalysts and additives in one pot. This protocol highlights dual roles of 4-hydroxycoumarins which were not only used as reactants but also activated DMSO to provide one-carbon unit in the desired products.

Automated summary

A substrate-induced synthesis of 6H-Chromeno[4,3-b]quinolin-6-ones directly from anilines, 4-hydroxycoumarins, and DMSO without any catalysts and additives in one pot has been developed. This protocol highlights the dual roles of 4-hydroxycoumarins, not only as reactants but also as activators of DMSO to provide a one-carbon unit in the desired products.