Iron-Catalyzed Silylation and Spirocyclization of Biaryl-Ynones: A Radical Cascade Process toward Silylated Spiro[5.5]trienones

Iron-catalyzed cascade silyl radical addition/6-exo-trig cyclization/dearomatization of biaryl ynones has been developed. This approach uses silane as the precursor of silyl radical as well as silylation reagent, 1,10-phenanthroline as the ligand, and tert-butyl hydroperoxide (TBHP) as the oxidant. By employing this tandem process, a series of silylated spiro[5.5]trienones were prepared.

Automated summary

In this study, an iron-catalyzed cascade reaction was developed for the synthesis of silylated spiro[5.5]trienones using silane as the precursor of silyl radical. The approach involved 1,10-phenanthroline as the ligand and tert-butyl hydroperoxide (TBHP) as the oxidant, leading to the formation of silylated compounds.