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Responsive Hydrogels Based on Triggered Click Reactions for Liver Cancer

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Hepatocellular carcinoma

Josep M. Llovet et al.

Summary: Liver cancer, particularly hepatocellular carcinoma (HCC), poses a significant global health challenge with rising incidence projected to exceed 1 million cases by 2025. Infection by hepatitis B and C viruses remains a major risk factor for HCC, while non-alcoholic steatohepatitis is emerging as a more common risk factor in Western countries. Advances in systemic therapies for HCC, including immunotherapies and targeted therapies, are expected to revolutionize the management of this disease.

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Reduction-Responsive Chemo-Capsule-Based Prodrug Nanogel for Synergistic Treatment of Tumor Chemotherapy

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ACS APPLIED MATERIALS & INTERFACES (2021)

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Harnessing Endogenous Stimuli for Responsive Materials in Theranostics

Alexander B. Cook et al.

Summary: Materials that respond to endogenous stimuli play a crucial role in enhancing spatiotemporal control in biomedical applications. These materials can be designed to undergo morphological or chemical changes in response to specific biological cues, offering promising opportunities for improving therapeutic efficacy and developing personalized healthcare systems. They can be engineered across different length scales to respond to endogenous signals such as enzymes, pH, glucose, and hold great potential for a wide range of applications.

ACS NANO (2021)

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Nanoparticle-Assembled Vacuolated Coacervates Control Macromolecule Spatiotemporal Distribution to Provide a Stable Segregated Cell Microenvironment

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ADVANCED MATERIALS (2021)

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A Virus-Mimicking Nucleic Acid Nanogel Reprograms Microglia and Macrophages for Glioblastoma Therapy

Xihui Gao et al.

Summary: Immunotherapy is a promising approach for treating cancers, but its effectiveness in glioblastoma treatment is limited due to the immunosuppressive tumor microenvironment. A virus-mimicking membrane-coated nucleic acid nanogel, Vir-Gel, has been developed to reprogram microglia and macrophages from a pro-invasive M2 phenotype to an anti-tumor M1 phenotype. This approach significantly enhances the targetability and cell uptake efficiency of therapeutic miRNA, demonstrating improved tumor inhibition efficacy.

ADVANCED MATERIALS (2021)

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Article Chemistry, Applied

A plant-inspired long-lasting adhesive bilayer nanocomposite hydrogel based on redox-active Ag/Tannic acid-Cellulose nanofibers

Yajun Chen et al.

Summary: In this study, plant-inspired adhesive hydrogels were designed based on reversible quinone/catechol chemistry for long-lasting and reusable applications in biomedical fields. These hydrogels showed high and repeatable adhesiveness, maintained their properties after extreme temperature storage, and were further enhanced by combining with electrospun nanofibers for potential wound healing applications.

CARBOHYDRATE POLYMERS (2021)

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Poly ethylene glycol (PEG)-Related controllable and sustainable antidiabetic drug delivery systems

Yupeng Fu et al.

Summary: Polyethylene glycol (PEG) is a promising material for drug delivery due to its unique features including hydrophilicity, biocompatibility, and biodegradability；PEG molecules can protect delivery systems, reduce immunogenicity, and avoid undesirable enzymolysis；PEG has been widely applied in various delivery systems such as micelles, vesicles, nanoparticles, and hydrogels.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

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Hyaluronic acid electrospinning: Challenges, applications in wound dressings and new perspectives

Karine Cappuccio Castro et al.

Summary: Hyaluronic acid is recognized as an efficient biopolymer for biomedical applications, especially in wound dressing construction. Electrospinning technology combined with the functional properties of HA can produce multifunctional nanofiber structures that promote quick skin recovery.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Design and characterization of a novel pH-sensitive biocompatible and multifunctional nanocarrier for in vitro paclitaxel release

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Summary: The novel nanocomposite PTX/N-GQDs/CoFe2O4/LDH shows excellent biocompatibility, slow-release capability, and significant growth inhibition effect on MCF7 breast cancer cells.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Tailoring the assembly of collagen fibers in alginate microspheres

Sarah Lehnert et al.

Summary: The use of microspheres in cell-laden biomaterials offers advantages such as high surface-to-volume ratio, but the assembly of collagen fibers in alginate matrix requires further investigation. Addition of small polar molecules and careful selection of gelling buffer can aid the assembly process in gelled alginate matrix.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Chemistry, Multidisciplinary

Ultrasound-Mediated Remotely Controlled Nanovaccine Delivery for Tumor Vaccination and Individualized Cancer Immunotherapy

Zhouqi Meng et al.

Summary: This study presents an ultrasound-responsive self-healing hydrogel system for controlled tumor vaccine release and personalized cancer immunotherapy. Through multiple ultrasound treatments, nanovaccines could be repeatedly released from the gel to elicit antitumor immune responses, effectively inhibiting established tumors and preventing postoperative tumor metastases and recurrence.

NANO LETTERS (2021)

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Review Gastroenterology & Hepatology

Locoregional therapies in the era of molecular and immune treatments for hepatocellular carcinoma

Josep M. Llovet et al.

Summary: Locoregional therapies, including local ablation and transarterial chemoembolization, play a crucial role in the management of hepatocellular carcinoma. Recent studies have shown potential benefits of combining these local therapies with systemic treatments, such as molecular therapies, to enhance therapeutic effects.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2021)

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Article Chemistry, Multidisciplinary

Nanostructure of Functional Larotaxel Liposomes Decorated with Guanine-Rich Quadruplex Nucleotide-Lipid Derivative for Treatment of Resistant Breast Cancer

Xueqi Li et al.

Summary: A functional nanomedicine based on larotaxel liposomes decorated with guanine-rich quadruplex nucleotide-lipid derivative was developed for the treatment of resistant breast cancer. The nanotechnology exhibited long circulatory effect, targeted capability, and significant anticancer efficacy in resistant cancer-bearing mice. The study also revealed the mechanism of action, including blocking microtubule depolymerization and inhibiting antiapoptotic protein activity.

SMALL (2021)

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Article Chemistry, Multidisciplinary

Injectable Immunotherapeutic Thermogel for Enhanced Immunotherapy Post Tumor Radiofrequency Ablation

Muchao Chen et al.

Summary: This research utilizes a strategy to block rho-associated kinases (ROCK) to amplify immune responses triggered by tumor radiofrequency ablation (RFA), enhancing the phagocytosis capacity of dendritic cells (DCs) and effectively activating T cell mediated anti-tumor immune responses, significantly improving the therapeutic efficiency of RFA.

SMALL (2021)

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Article Nanoscience & Nanotechnology

Free Radical Polymerization of Gold Nanoclusters and Hydrogels for Cell Capture and Light-Controlled Release

Shuxian Zhu et al.

Summary: Gold nanoclusters copolymerized with hydrogels exhibit good stability, efficient photothermal conversion, and high thermoresponsiveness. The C=C bonds on the surface of AuNCs protect the structure and connect them with polymer chains, improving the mechanical properties of the hydrogels.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Engineering, Biomedical

Catechol-metal coordination-mediated nanocomposite hydrogels for on-demand drug delivery and efficacious combination therapy

Guoru Dai et al.

Summary: A magnetic nanocomposite hydrogel crosslinked by metal-ligand coordination was designed and synthesized to enhance mechanical strength and controllable drug release. The hydrogel showed longer retention time and effective anticancer potency both in vitro and in vivo, mediated by a combination therapy of chemotherapy and hyperthermia. Single-modality treatment with either chemotherapy or hyperthermia alone failed to achieve the same efficacy.

ACTA BIOMATERIALIA (2021)

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Review Engineering, Biomedical

PEG-based thermosensitive and biodegradable hydrogels

Jiayue Shi et al.

Summary: This paper outlines the recent progress of poly(ethylene glycol) (PEG)-based biodegradable thermosensitive hydrogels in the biomedical field, emphasizing their potential applications in drug release and cell growth. Thermosensitive hydrogels with designed and regulated properties exhibit excellent biocompatibility and degradability, providing a demonstration for the design of new thermogelling systems.

ACTA BIOMATERIALIA (2021)

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Article Chemistry, Multidisciplinary

Reconstructable Gradient Structures and Reprogrammable 3D Deformations of Hydrogels with Coumarin Units as the Photolabile Crosslinks

Chao Nan Zhu et al.

Summary: A hydrogel with reversible photo-crosslinks has been developed, allowing for the reprogramming of gradient structures and 3D deformations into various configurations. The hydrogel is fabricated by micellar polymerization of hydrophobic coumarin monomer and hydrophilic acrylic acid, with hexadecyltrimethylammonium chloride micelles enhancing local concentration of coumarin units and improving mechanical properties by forming polyelectrolyte/surfactant complexes. High-efficiency photodimerization and photocleavage reactions of coumarins enable reversible tuning of the network structure of the hydrogel, which can be patterned with different gradient structures through photolithography for versatile functionalities.

ADVANCED MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Interactive Materials for Bidirectional Redox-Based Communication

Jinyang Li et al.

Summary: Emerging research shows that biology uses diffusible redox-active molecules for communication across biological systems and kingdoms. This redox modality also creates opportunities for interactive materials that can communicate with living systems. The study demonstrates that catecholic materials can participate in redox-based interactions to elicit specific biological responses, suggesting natural phenolics may be a ubiquitous example of interactive materials.

ADVANCED MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Epigenetic Remodeling Hydrogel Patches for Multidrug-Resistant Triple-Negative Breast Cancer

Xiaoyuan Ji et al.

Summary: The hydrogel patch designed to modulate the plasticity of T-ICs in TNBC shows promising results in improving chemosensitivity, enhancing tumor immunogenicity, and increasing T-cell infiltration. Additionally, the patch efficiently suppresses tumor growth, postsurgical relapse, and metastasis with a single dose, demonstrating superior efficacy against multidrug resistance.

ADVANCED MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Light-Triggered In Situ Gelation of Hydrogels using 2D Molybdenum Disulfide (MoS2) Nanoassemblies as Crosslink Epicenter

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Summary: Light-responsive biomaterials based on NIR-triggered in situ gelation system using defect-rich 2D MoS2 nanoassemblies and thiol-functionalized thermoresponsive polymer without a photoinitiator have been introduced. This system leverages the photothermal characteristics of MoS2 and intrinsic phase transition ability of the thermoresponsive polymer upon exposure to NIR radiation. The crosslinked gel shows potential for NIR light-responsive release of encapsulated therapeutics and various biomedical applications.

ADVANCED MATERIALS (2021)

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Article Biochemistry & Molecular Biology

Abiotic Stimuli-Responsive Protein Affinity Reagent for IgG

Shunsuke Onogi et al.

Summary: This approach utilizes synthetic hydrogel copolymers to selectively capture proteins by tuning their composition and polymerization conditions. The protein affinity reagent (PAR) can be rapidly synthesized in a chemistry laboratory without the need for living cells, and can reversibly capture and release proteins without denaturation under specific conditions.

BIOMACROMOLECULES (2021)

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Article Oncology

Sustained and targeted delivery of siRNA/DP7-C nanoparticles from injectable thermosensitive hydrogel for hepatocellular carcinoma therapy

Binyan Zhao et al.

Summary: The combination of GalNAc-Pin1 siRNA with DP7-C nanoparticles and hydrogel enhances the stability and inhibitory effects of Pin1 siRNA, showing potential therapeutic efficacy in a liver cancer model.

CANCER SCIENCE (2021)

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Article Chemistry, Applied

Injectable DMEM-induced phenylboronic acid-modified hyaluronic acid self-crosslinking hydrogel for potential applications in tissue repair

Huichang Gao et al.

Summary: A novel injectable DMEM-induced phenylboronic acid-modified hyaluronic acid self-crosslinking hydrogel was designed in this study, which exhibited good self-healing properties and tissue adhesion. It is capable of supporting cell loading and proliferation, making it a promising candidate for tissue repair materials.

CARBOHYDRATE POLYMERS (2021)

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Article Chemistry, Multidisciplinary

Near-Infrared Light-, Magneto-, and pH-Responsive GO-Fe3O4/Poly(N-isopropylacrylamide)/alginate Nanocomposite Hydrogel Microcapsules for Controlled Drug Release

Yuan Cao et al.

Summary: Responsive hydrogels have been widely used in biomedical science and engineering fields, particularly for drug delivery, although challenges in drug-delivery efficiency still exist when environmental stimuli are weak. The demand for hydrogel-based drug delivery systems has led to the search for new strategies, such as the application of nanocomposite hydrogels to enhance versatility and flexibility. This study introduces a novel nanocomposite hydrogel microcapsule drug delivery system that shows promise in achieving NIR light-, magneto-, and pH-responsive drug release, demonstrating potential for disease treatment.

LANGMUIR (2021)

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Article Materials Science, Biomaterials

Different hydration states and passive tumor targeting ability of polyethylene glycol-modified dendrimers with high and low PEG density

Ayako Tsujimoto et al.

Summary: This study explores the tripartite relationship among PEG density, hydration state, and passive tumor targeting property in PEGylated dendrimers. It is the first report to demonstrate the hydration state of a drug carrier and discuss its relationship with biodistribution. Fully PEGylated dendrimers exhibited similar hydration behavior to PEG and passive tumor targeting property, while partially PEGylated dendrimers showed different hydration behavior and lacked the passive tumor targeting property.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Multidisciplinary Sciences

NASH limits anti-tumour surveillance in immunotherapy-treated HCC

Dominik Pfister et al.

Summary: The study investigated the impact of NASH on immunotherapy response in HCC patients and found that NASH-HCC may be less responsive to immunotherapy. Aberrant T cell activation caused by NASH-related tissue damage led to impaired immune surveillance in HCC patients.

NATURE (2021)

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Review Pharmacology & Pharmacy

Delivery strategies of amphotericin B for invasive fungal infections

Xiaochun Wang et al.

Summary: Invasive fungal infections are a growing public concern for clinicians, with amphotericin B being the most frequently used drug for treatment. Nanocarriers for AmB delivery show promising efficacy and safety for managing IFIs. Future studies are recommended for applying AmB in combating IFIs.

ACTA PHARMACEUTICA SINICA B (2021)

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Article Chemistry, Multidisciplinary

An Investigation of the Interaction between Bovine Serum Albumin-Conjugated Silver Nanoparticles and the Hydrogel in Hydrogel Nanocomposites

Berhanu Zewde et al.

Summary: Nanocomposite hydrogels with stimuli-responsive properties are synthesized using click chemistry to crosslink hydrogel precursors and encapsulate silver nanoparticles. Spectroscopic techniques reveal interactions between the nanoparticles and the hydrogel, where polyethylene glycol rearranges while hyaluronic acid interacts with bovine serum albumin on the nanoparticles. The hydrogel nanocomposite demonstrates antibacterial activity against Gram-positive/Gram-negative bactericides, supporting time-based nanoparticle release.

ACS OMEGA (2021)

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Article Nanoscience & Nanotechnology

Molybdenum Trioxide Quantum Dot-Encapsulated Nanogels for Virus Detection by Surface-Enhanced Raman Scattering on a 2D Substrate

Ojodomo J. Achadu et al.

Summary: The use of nanogels to modulate SERS activities, encapsulate SERS nanotags, and create hotspot regions has provided a biosensing platform for ultrasensitive immunoassays of HEV and NoV, achieving extremely low detection limits.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Nanoscience & Nanotechnology

High-Strength, Strongly Bonded Nanocomposite Hydrogels for Cartilage Repair

Shikha Awasthi et al.

Summary: Polyacrylamide-based hydrogels were strengthened using titanium oxide (TiO2) and carbon nanotubes (CNTs) alone and combined in a matrix, resulting in improved mechanical properties and puncture resistance. The synergistic effect of TiO2 and CNT nanoparticles with PAM led to high compressive strength and elastic modulus, as well as significant self-healing and cytocompatibility. The stability and structural features of the PAM-TiO2-CNT composite were analyzed using density functional theory (DFT), showing promising potential for cartilage repair applications.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Chemistry, Multidisciplinary

Electro-Mechanochemical Gating of a Metal-Phenolic Nanocage for Controlled Guest-Release Self-Powered Patches and Injectable Gels

Gyeonghyeon Choi et al.

Summary: The study introduces a facile method to prepare electro-mechanochemically responsive soft gel composites with molecular gatekeeper-based nanocontainers. These composites exhibit self-healing ability and controlled guest molecule release in response to electrical and mechanical stimuli, allowing for remotely controllable drug-delivery applications.

ACS NANO (2021)

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Article Engineering, Biomedical

Construction of a photothermal hydrogel platform with two-dimensional PEG@zirconium-ferrocene MOF nanozymes for rapid tissue repair of bacteria-infected wounds

Xin Wang et al.

Summary: This study successfully developed a powerful hydrogel with bactericidal properties and rapid tissue repair effects for the treatment of bacterial wound infections. The synergistic effect of phototherm-nanozyme-hydrogel holds great potential in bacterial wound infection therapy.

ACTA BIOMATERIALIA (2021)

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Article Engineering, Biomedical

Precise in-situ release of microRNA from an injectable hydrogel induces bone regeneration

Minfeng Gan et al.

Summary: The study demonstrates the effective delivery and precise release of cholesterol-modified non-coding microRNA in bone defects using an injectable poly(ethylene glycol) hydrogel, showing significantly improved bone regeneration outcomes.

ACTA BIOMATERIALIA (2021)

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Review Engineering, Biomedical

Engineering nanocomposite hydrogels using dynamic bonds

Cheng-Hsun Lu et al.

Summary: Nanocomposite hydrogels synthesized using dynamic bonds, including both dynamic covalent and non-covalent bonds, offer versatile properties for biomedical applications. Dynamic bonds provide self-healing and stimulus responsiveness to the hydrogels, and their presence at polymer interfaces determines the role of particles as fillers or crosslinkers in the hydrogels. Multiple examples of NC hydrogels fabricated using dynamic bonds are discussed in this review, highlighting their design, preparation, properties, applications, and future prospects.

ACTA BIOMATERIALIA (2021)

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Article Chemistry, Multidisciplinary

Sono-Controllable and ROS-Sensitive CRISPR-Cas9 Genome Editing for Augmented/Synergistic Ultrasound Tumor Nanotherapy

Yinying Pu et al.

Summary: A sono-controllable and ROS-sensitive nanomedicine, P/M@CasMTH1, has been developed for enhanced sonodynamic therapy by disrupting MTH1 gene in tumor cells, leading to cellular apoptosis and tumor suppression.

ADVANCED MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Hydrophilicity-Hydrophobicity Transformation, Thermoresponsive Morphomechanics, and Crack Multifurcation Revealed by AIEgens in Mechanically Strong Hydrogels

Yubing Hu et al.

Summary: The biomimetic exploration of stimuli-responsive and crack-resistant hydrogels is important, but limited by insufficient mechanism study due to the lack of imaging techniques at the mesoscale level. By incorporating aggregation- and polarity-sensitive fluorescent probes in a poly(N-isopropylacrylamide) network, a series of composite hydrogels with compartmentalized thermal response are designed. The fluorescence technique is explored as a powerful tool to visualize the hydrophilicity-hydrophobicity transformation and composition-dependent microphase separation in the hydrogels, leading to the proposal of a concept of morphomechanics with comprehensive mechanism clarification. The thermoresponsive toughening is attributed to the formation of multiple noncovalent interactions and conformational changes of PNIPAM chains, while the enhanced fracture energy by crack multifurcation is related to the tearing-like disruption of weak interfaces between separated phases.

ADVANCED MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Design and Use of a Thermogelling Methylcellulose Nanoemulsion to Formulate Nanocrystalline Oral Dosage Forms

Liang-Hsun Chen et al.

Summary: This study successfully developed a new thermogelling nanoemulsion and a thermal dripping method for efficient preparation of composite particles with a methylcellulose (MC) matrix embedded with precisely controlled API nanocrystals. By combining a fast-eroding MC matrix and fast-dissolving API nanocrystals, a fast and tunable release performance was achieved. The versatile thermal processing approach allows for the easy formulation of a wide variety of dosage forms, showing great promise for more efficient formulation of oral drug products with high quality and tunable fast release.

ADVANCED MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Anisotropically Fatigue-Resistant Hydrogels

Xiangyu Liang et al.

Summary: Nature utilizes inherent structures across multiple length-scales to build biological materials with exceptional mechanical performances, surpassing artificial materials. A simple and universal strategy has been developed to significantly increase the fatigue thresholds of conventional hydrogels, making them durable alternatives to most synthetic soft materials. These fatigue-resistant hydrogels show high-performance and cost-effective features, suitable for various applications such as robotics and artificial muscles.

ADVANCED MATERIALS (2021)

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Editorial Material Surgery

Discovery and Innovation in Surgery Chance and Necessity

Henri Bismuth

ANNALS OF SURGERY (2021)

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Article Engineering, Biomedical

Construction and evaluation of novel αvβ3 integrin ligand-conjugated ultrasmall star polymer micelles targeted glomerular podocytes through GFB permeation

Chengyuan Huang et al.

Summary: The novel ultrasmall micelles, with specific affinity to podocytes mediated by a novel linear RWrNM peptide, demonstrated promising drug delivery strategy for actively targeted therapy of CKD in vitro and in vivo.

BIOMATERIALS (2021)

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Article Chemistry, Applied

Nanocomposite hydrogel based on sodium alginate, poly (acrylic acid), and tetraamminecopper (II) sulfate as an efficient dye adsorbent

Tannaz Mozaffari et al.

Summary: A novel nanocomposite hydrogel with high dye adsorption capacity was synthesized by radical polymerization, and it was found to exhibit efficient removal of dyes and good recyclability under certain conditions through structural and dye adsorption studies.

CARBOHYDRATE POLYMERS (2021)

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Article Biophysics

Design, fabrication and drug release potential of dual stimuli-responsive composite hydrogel nanoparticle interfaces

Narsimha Mamidi et al.

Summary: CNPs, as a type of nanocomposite hydrogel particles, were fabricated using an ionic gelation strategy and demonstrated dual (pH and thermo)-responsive controlled drug release in vitro. The results showed that CNPs disassembled at 55 degrees C to release the encapsulated drug molecules in a controlled fashion, indicating their potential as a promising drug delivery platform for the GI tract and colon targeted drug delivery.

COLLOIDS AND SURFACES B-BIOINTERFACES (2021)

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Review Biochemistry & Molecular Biology

Stimuli-Responsive Poly(aspartamide) Derivatives and Their Applications as Drug Carriers

Guangyan Zhang et al.

Summary: Poly(aspartamide) derivatives, with excellent biocompatibility and biodegradability, are suitable for biomedical applications. Stimuli-responsive poly(aspartamide) derivatives can be used for drug release and control.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Nanoscience & Nanotechnology

Intratumoral Administration of Thermosensitive Hydrogel Co-Loaded with Norcantharidin Nanoparticles and Doxorubicin for the Treatment of Hepatocellular Carcinoma

Benjian Gao et al.

Summary: An in situ drug-loaded injectable thermosensitive hydrogel system was designed for the simultaneous delivery of norcantharidin-loaded nanoparticles and doxorubicin to HCC tumors. The drug-loaded hydrogel exhibited excellent thermal-sensitive properties and sustained drug release, showing remarkable antiproliferative activity in vitro and significant antitumor efficacy in vivo, suggesting it as a promising strategy for HCC treatment.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Review Chemistry, Multidisciplinary

Magnetic-responsive hydrogels: From strategic design to biomedical applications

Zhenguang Li et al.

Summary: Magnetic-responsive hydrogels, prepared by embedding magnetic nanomaterials into hydrogel networks, have advantages such as rapid magnetic response, precise control, and non-invasively remote operation for biomedical applications. This review summarizes the synthetic methods, roles in different applications, and future perspectives of magnetic hydrogels.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Engineering, Environmental

Smart hydrogel-microsphere embedded silver nanoparticle catalyst with high activity and selectivity for the reduction of 4-nitrophenol and azo dyes

Dambarudhar Parida et al.

Summary: A simple method is used to prepare a hydrogel microparticle catalyst embedded with silver nanoparticles, which can efficiently reduce specific pollutants and deactivate under basic conditions.

JOURNAL OF HAZARDOUS MATERIALS (2021)

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Article Materials Science, Biomaterials

Chitosan-poloxamer-based thermosensitive hydrogels containing zinc gluconate/recombinant human epidermal growth factor benefit for antibacterial and wound healing

Shiyu Lin et al.

Summary: The study developed a thermosensitive hydrogel based on chitosan/poloxamer-75 containing zinc gluconate and recombinant human epidermal growth factor as a dressing for skin wound treatment, showing antibacterial and biofilm clearing activities. Through experiments and animal models, the dressing promoted wound healing and tissue repair.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Chemistry, Multidisciplinary

Alginate-Based Amphiphilic Block Copolymers as a Drug Codelivery Platform

Yunpeng Feng et al.

Summary: Structured nanoassemblies are biomimetic structures with potential applications in fields ranging from nanomedicine to catalysis. Self-assembling ABC-type alginate-based triblock copolymers, with the backbones of three distinct biomaterials, were synthesized using a facile conjugation approach. These particles provide a versatile platform for co-encapsulation of hydrophilic and hydrophobic small molecules, spatiotemporal release, and show promise as a drug delivery system for combination therapy.

NANO LETTERS (2021)

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Article Multidisciplinary Sciences

Tough hydrogels with rapid self-reinforcement

Chang Liu et al.

Summary: The study introduces a damageless reinforcement strategy for hydrogels using strain-induced crystallization, which significantly enhances the toughness and enables almost 100% rapid recovery of extension energy.

SCIENCE (2021)

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Article Chemistry, Multidisciplinary

Particle Integrity and Size Effect on the Journey of Polymeric Nanocarriers in Zebrafish Model and the Correlation with Mice

Jinsong Tao et al.

Summary: The study investigates the biofate correlation of different-sized poly(caprolactone) nanocarriers in zebrafish and mice, showing that PEGylated PCL NCs have higher integrity in both models. Small PEG-PCL NCs have longer circulation time, while large ones have higher macrophage sequestration in both species. The findings suggest that 7 dpf zebrafish are suitable for in vivo screening of nanocarriers and predicting their performance in rodents.

SMALL (2021)

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Article Multidisciplinary Sciences

Ultra-fast single-crystal polymerization of large-sized covalent organic frameworks

Lan Peng et al.

Summary: This study reveals that supercritical CO2 significantly accelerates single-crystal polymerization, allowing for the production of large-sized, high-quality 2D COF single crystals.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

Geometrically encoded SERS nanobarcodes for the logical detection of nasopharyngeal carcinoma-related progression biomarkers

Duo Lin et al.

Summary: The study developed 14 distinct geometrically controlled metal carbonyl tags for multiplexed detection of nasopharyngeal carcinoma biomarkers from patient blood, demonstrating high sensitivity and multiplexing capabilities.

NATURE COMMUNICATIONS (2021)

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Review Nanoscience & Nanotechnology

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

Sepand Tehrani Fateh et al.

Summary: The field of theranostics has been rapidly growing, with nanotechnology playing a major role in this growth. Nanomaterials can respond to a variety of stimuli and produce imaging signals and therapeutic effects, often leading to cell death. Combining ultrasound with rationally designed nanoparticles is attractive for theranostics, and the mechanisms of ultrasound interactions can result in drug release, cell death, and enhanced imaging.

BEILSTEIN JOURNAL OF NANOTECHNOLOGY (2021)

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Article Polymer Science

Magnetic Field Dynamic Strategies for the Improved Control of the Angiogenic Effect of Mesenchymal Stromal Cells

Ana C. Manjua et al.

Summary: This work demonstrates the ability to remotely control the paracrine performance of MSCs in secreting VEGF-A by modulation of an external magnetic field. Higher magnetic field intensity is associated with increased cell death and poor angiogenic effect. Dynamic magnetic field and higher frequency stimulation improve the angiogenic performance of endothelial cells.

POLYMERS (2021)

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Article Pharmacology & Pharmacy

ROS-Eliminating Carboxymethyl Chitosan Hydrogel to Enhance Burn Wound-Healing Efficacy

Cheng Yang et al.

Summary: The ROS-sensitive hydrogel prepared in this study showed strong free radical scavenging ability, accelerated wound healing, and promoted tissue regeneration in experiments.

FRONTIERS IN PHARMACOLOGY (2021)

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Review Chemistry, Multidisciplinary

Protein-Based Nanohydrogels for Bioactive Delivery

Subhash Chander et al.

Summary: Hydrogels are polymer materials with a unique network structure capable of absorbing water and biological fluids. Nanohydrogels, composed of diverse synthetic or natural polymers, possess high biocompatibility and metabolic degradability. Protein nanohydrogels, with various preparation methods and broad applications in medicine, offer potential in diverse disciplines.

FRONTIERS IN CHEMISTRY (2021)

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Article Multidisciplinary Sciences

Snake extract-laden hemostatic bioadhesive gel cross-linked by visible light

Yicheng Guo et al.

Summary: The study introduces a novel visible light-induced blood-resistant hemostatic adhesive (HAD) that efficiently achieves hemostasis by activating and aggregating platelets. HAD demonstrates excellent hemostatic performance on liver incision and severed rat tail, significantly reducing blood loss.

SCIENCE ADVANCES (2021)

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Article Nanoscience & Nanotechnology

High-Efficient and Dosage-Controllable Intracellular Cargo Delivery through Electrochemical Metal-Organic Hybrid Nanogates

Bowen Zhang et al.

Summary: The combination of hollow nanostructures and electroporation allows for the delivery of versatile cargos into adhesive cells at low voltages, utilizing a metal-organic hybrid nanotube stamp. This approach improves cell viability and demonstrates efficient transport of small and large molecules into the cells.

SMALL SCIENCE (2021)

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Article Materials Science, Biomaterials

Therapeutic effects of boronate ester cross-linked injectable hydrogels for the treatment of hepatocellular carcinoma

Jae Min Jung et al.

Summary: A thermo-responsive hydrogel was developed for targeted delivery of drugs to tumor tissues, showing stable formation in vivo and potential for suppressing tumor growth. This study suggests that the pH-responsive drug-releasing hydrogel has great promise for localized anticancer therapy.

BIOMATERIALS SCIENCE (2021)

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Article Medicine, Research & Experimental

Macrophage-mediated tumor homing of hyaluronic acid nanogels loaded with polypyrrole and anticancer drug for targeted combinational photothermo-chemotherapy

Tingting Xiao et al.

Summary: The study developed a novel nanosystem integrated with macrophages for tumor therapy. By encapsulating hyaluronic acid nanogels with polypyrrole photothermal agent and anticancer drug doxorubicin, tumor homing and combination photothermo-chemotherapy were achieved. The results showed that the hybrid nanosystem has good targeting capability and enhanced antitumor therapy effect.

THERANOSTICS (2021)

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Review Chemistry, Physical

Structure Engineering of 2D Materials toward Magnetism Modulation

Zijing Zhao et al.

Summary: The modulation of 2D magnetism through structure engineering has attracted significant attention recently. It is considered as an effective method to enrich the family of 2D magnetic materials and expand their application prospects. Further research is focused on inducing long-range magnetic ordering into nonmagnetic materials and regulating the native magnetism of intrinsic magnetic materials.

SMALL STRUCTURES (2021)

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Review Engineering, Biomedical

Recent advances in design and applications of biomimetic self-assembled peptide hydrogels for hard tissue regeneration

Haniyeh Najafi et al.

Summary: Self-assembled peptide hydrogels, as a new generation of biomaterials, show excellent properties for hard tissue repair and regeneration, with potential applications in mimicking extracellular matrix and enhancing tissue regeneration compared to conventional methods.

BIO-DESIGN AND MANUFACTURING (2021)

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Article Chemistry, Analytical

Thermo-sensitivity of hybrid nanogels for specific endogenous hydrogen sulfide detection and efficient flash chill treatment

Xu-hao Sun et al.

Summary: Thermo-responsive nanogels with fluorescent properties were prepared using a simple method and utilized for cell apoptosis and hydrogen sulfide detection. The nanogels show bright photoluminescence and outstanding thermo-responsive properties, making them suitable for various biomedical applications.

ANALYTICAL METHODS (2021)

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Article Pharmacology & Pharmacy

PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application

Yue Su et al.

Summary: Biodegradable microspheres are widely used in medicine for drug delivery with advantages of low dose and low side effects. PLGA is one of the most widely used biodegradable materials with good biocompatibility. PLGA microspheres have been extensively studied and applied in drug delivery.

DRUG DELIVERY (2021)

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Review Polymer Science

Nanogels as a Versatile Drug Delivery System for Brain Cancer

Brielle Stawicki et al.

Summary: Chemotherapy and radiation are mainstays in cancer treatment globally, but some therapies have limited specificity and cause harsh side effects in patients. Nanogels, as a unique drug delivery system, show promise in the treatment of brain cancer, despite complications such as handling and chemical stability. Ongoing development of nanogels offers a patient-centered approach for managing brain cancer.

GELS (2021)

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Article Nanoscience & Nanotechnology

3D Electrospun Synthetic Extracellular Matrix for Tissue Regeneration

Yingchun Su et al.

Summary: Electrospinning is a versatile micro-/nanofiber fabrication technology that produces fibers with high surface area, desired mechanical properties, and controlled topography, mimicking the structure of extracellular matrices (ECM) for tissue regeneration. This review systematically summarizes recent advances in electrospinning technology and its applications in various tissue regeneration fields, discussing challenges and future prospects. Furthermore, the key challenge of scaling up electrospinning for industrial applications is outlined.

SMALL SCIENCE (2021)

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Review Nanoscience & Nanotechnology

Hybrid-Filler Stretchable Conductive Composites: From Fabrication to Application

Guolin Yun et al.

Summary: Stretchable conductive composites (SCCs) are elastomer matrices filled with conductive fillers, combining the conductivity of metals and carbon materials with the flexibility of polymers. Introducing secondary fillers can enhance the electrical conductivity of the composites, improve thermal conductivity and mechanical properties.

SMALL SCIENCE (2021)

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Article Nanoscience & Nanotechnology

Monitoring Lipolysis by Sensing Breath Acetone down to Parts-per-Billion

Ines C. Weber et al.

Summary: Mobile health technologies offer new possibilities for managing metabolic diseases, with breath acetone monitoring showing potential for personalized treatments. A low-cost detector has been developed to accurately track lipolysis dynamics, suitable for metabolic assessment in various settings.

SMALL SCIENCE (2021)

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Article Pharmacology & Pharmacy

Development of cisplatin-loaded hydrogels for trans-portal vein chemoembolization in an orthotopic liver cancer mouse model

Xinxiang Yang et al.

Summary: The study demonstrated the potential of IPN hydrogel as an effective embolic material for trans-portal vein chemoembolization in inhibiting tumor growth, reducing angiogenesis, and promoting tumor apoptosis in an orthotopic HCC mouse model. Cisplatin-loaded IPN hydrogel showed significant tumor growth inhibition and decreased tumor cell survival compared to untreated groups.

DRUG DELIVERY (2021)

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Review Chemistry, Multidisciplinary

Biomolecule-assisted synthesis of biomimetic nanocomposite hydrogel for hemostatic and wound heating applications

Sujoy K. Das et al.

Summary: Hydrogels are water-rich structures formed by crosslinking of hydrophilic monomers, mimicking the extracellular matrix of biological soft tissues, and having widespread applications in the biomedical field. Nanocomposite hydrogels incorporate diverse nanomaterials into soft polymer matrixes to enhance the physical, chemical, and biological properties of the hydrogels, resulting in improved characteristics.

GREEN CHEMISTRY (2021)

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Review Materials Science, Biomaterials

Nanocomposite adhesive hydrogels: from design to application

Yuchen Zhang et al.

Summary: Hydrogel adhesion has become increasingly important in the past decade, with factors such as chemistries of bonds, topologies of connection, and mechanisms of energy dissipation affecting adhesion. Strategies like surface modification and the use of nanocomposites help achieve strong hydrogel adhesion by forming strong bonds that lower adhesion energy and offer energy dissipation. This review provides a comprehensive overview of nanocomposite adhesive hydrogels and offers valuable insights for their design and further development.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Article Nanoscience & Nanotechnology

Silk Nanococoons: Bio-Nanoreactors for Enzymatic Catalytic Reactions and Applications to Alcohol Intoxication

Zhengwei Chen et al.

Summary: The development of a silk fibroin nanococoons system inspired by silk cocoons provides a bio-protective environment for enzymatic activities, enhancing enzymatic stability and efficacy. Mutual templated crystallization between enzymes and silk fibroin molecules prevents enzyme unfolding, showing significant potential applications in biomedicine.

SMALL SCIENCE (2021)

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Review Nanoscience & Nanotechnology

Functional Nucleic-Acid-Decorated Spherical Nanoparticles: Preparation Strategies and Current Applications in Cancer Therapy

Min Zhu et al.

Summary: Functional nucleic acid-decorated spherical nanoparticles (FSNPs) show unique capabilities for cancer therapy, such as resistance to nuclease degradation and ability to cross the blood-brain barrier. They can be used for tumor-targeted drug delivery, controlled drug release, overcoming physiological or pathological barriers, as well as reversing resistance to chemotherapy and activating anti-tumor immune responses.

SMALL SCIENCE (2021)

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Review Nanoscience & Nanotechnology

Nanoarchitectonics Revolution and Evolution: From Small Science to Big Technology

Katsuhiko Ariga

Summary: With advancements in material synthesis, the importance of structural regulation has been realized, leading to the emergence of a novel concept known as nanoarchitectonics that combines nanotechnology with other scientific disciplines to create functional material systems using contributions from small objects and nano-units. This approach allows for the construction of unusual functional systems, such as brain-like information processing and probe-tip-mediated organic reactions, by utilizing nano-units in conjunction with various research fields.

SMALL SCIENCE (2021)

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Article Chemistry, Multidisciplinary

Dual Physically Cross-Linked Hydrogels Incorporating Hydrophobic Interactions with Promising Repairability and Ultrahigh Elongation

Xinyao Liu et al.

Summary: In this study, novel dual physically cross-linked (DPC) hydrogels were developed by incorporating cellulose nanocrystal (CNC) or hydrophobized CNC (CNC-C8) into polymers physically cross-linked by hydrophobic forces. The CNC-C8 DPC hydrogels demonstrated stronger tensile strength and excellent elongation compared to the optimum CNC DPC hydrogels, showcasing the enhanced mechanical properties achieved through introduced hydrophobic interactions. Additionally, these DPC hydrogels could be easily repaired with tetrahydrofuran (THF) while maintaining good tensile stress and elongation behaviors.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Medicine, Research & Experimental

Nanodefensin-encased hydrogel with dual bactericidal and pro-regenerative functions for advanced wound therapy

Gan Luo et al.

Summary: NDEFgel, a nanoengineered human alpha-defensin 5 encased hydrogel, was developed and shown to promote wound healing by modulating fibroblast behavior and upregulating genes related to collagen deposition. Pluronic F127 (Plu) hydrogel was identified as the optimal carrier for ND delivery, exhibiting controlled release and good compatibility. These findings suggest that NDEFgel may offer a promising dual-action therapeutic option for advanced wound management in the future.

THERANOSTICS (2021)

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Article Multidisciplinary Sciences

NASH limits anti-tumour surveillance in immunotherapy-treated HCC

Dominik Pfister et al.

Summary: The text discusses the impact of NASH on the development of HCC and the effect of immunotherapy, revealing the accumulation of exhausted and unconventionally activated CD8(+)PD1(+) T cells in NASH-affected livers. In preclinical models of NASH-induced HCC, anti-PD1 treatment led to an increase in HCC, with CD8(+) T cells contributing to this increase.

NATURE (2021)

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Article Chemistry, Multidisciplinary

Enzyme-Instructed Self-Assembly (EISA) and Hydrogelation of Peptides

Jie Gao et al.

ADVANCED MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Instant Thermal Switching from Soft Hydrogel to Rigid Plastics Inspired by Thermophile Proteins

Takayuki Nonoyama et al.

ADVANCED MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Artificial Perspiration Membrane by Programmed Deformation of Thermoresponsive Hydrogels

Junsoo Kim et al.

ADVANCED MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Thermosensitive Hydrogel Based on PEO-PPO-PEO Poloxamers for a Controlled In Situ Release of Recombinant Adeno-Associated Viral Vectors for Effective Gene Therapy of Cartilage Defects

Henning Madry et al.

ADVANCED MATERIALS (2020)

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Article Radiology, Nuclear Medicine & Medical Imaging

MR Imaging Enables Real-Time Monitoring of In Vitro Electrolytic Ablation of Hepatocellular Carcinoma

Elliot J. Stein et al.

JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY (2020)

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Article Nanoscience & Nanotechnology

Dual pH-Responsive Hydrogel Actuator for Lipophilic Drug Delivery

Zilong Han et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Engineering, Biomedical

Double-crosslinked nanocomposite hydrogels for temporal control of drug dosing in combination therapy

Can Wu et al.

ACTA BIOMATERIALIA (2020)

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Article Chemistry, Multidisciplinary

Ultrasound-Triggered Enzymatic Gelation

Valeria Nele et al.

ADVANCED MATERIALS (2020)

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Article Biochemical Research Methods

Preparation of Aptamer Responsive DNA Functionalized Hydrogels for the Sensitive Detection of α-Fetoprotein Using SERS Method

Qi Wang et al.

BIOCONJUGATE CHEMISTRY (2020)

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Article Chemistry, Multidisciplinary

Programmable Reversible Shape Transformation of Hydrogels Based on Transient Structural Anisotropy

Kangkang Liu et al.

ADVANCED MATERIALS (2020)

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Editorial Material Urology & Nephrology

Urologic Society for Transplantation and Renal Surgery 2020 Annual Meeting Abstracts

Alp Sener

CUAJ-CANADIAN UROLOGICAL ASSOCIATION JOURNAL (2020)

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Article Biochemistry & Molecular Biology

The effects of chemical crosslinking manners on the physical properties and biocompatibility of collagen type I/hyaluronic acid composite hydrogels

Weili Kong et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Article Pharmacology & Pharmacy

Therapeutic e fficacy of thermosensitive Pluronic hydrogel for codelivery of resveratrol microspheres and cisplatin in the treatment of liver cancer ascites

Qian Wen et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

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Article Chemistry, Multidisciplinary

Nanoparticle-hydrogel superstructures for biomedical applications

Yao Jiang et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Biochemistry & Molecular Biology

Development of PLGA-PEG-PLGA Hydrogel Delivery System for Enhanced Immunoreaction and Efficacy of Newcastle Disease Virus DNA Vaccine

Ying Gao et al.

MOLECULES (2020)

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Article Chemistry, Multidisciplinary

Multifunctional Supramolecular Hydrogel for Prevention of Epidural Adhesion after Laminectomy

Yan Wang et al.

ACS NANO (2020)

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Article Chemistry, Multidisciplinary

A Flexi-PEGDA Upconversion Implant for Wireless Brain Photodynamic Therapy

Daniel Boon Loong Teh et al.

ADVANCED MATERIALS (2020)

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Article Chemistry, Multidisciplinary

The Effect of Thiol Structure on Allyl Sulfide Photodegradable Hydrogels and their Application as a Degradable Scaffold for Organoid Passaging

F. Max Yavitt et al.

ADVANCED MATERIALS (2020)

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Review Chemistry, Multidisciplinary

Hydrogels and Hydrogel-Derived Materials for Energy and Water Sustainability

Youhong Guo et al.

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Ultrasound-Responsive Carriers for Therapeutic Applications

Rajeet Chandan et al.

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Redox-responsive functionalized hydrogel marble for the generation of cellular spheroids

Wahyu Ramadhan et al.

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Large-Scale Spinning Approach to Engineering Knittable Hydrogel Fiber for Soft Robots

Xiangyu Duan et al.

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Injectable and NIR-Responsive DNA-Inorganic Hybrid Hydrogels with Outstanding Photothermal Therapy

Bin Liu et al.

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100th Anniversary of Macromolecular Science Viewpoint: Re-Engineering Cellular Interfaces with Synthetic Macromolecules Using Metabolic Glycan Labeling

Ruben M. F. Tomas et al.

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Unravelling the Enzymatic Degradation Mechanism of Supramolecular Peptide Nanofibers and Its Correlation with Their Internal Viscosity

Yejiao Shi et al.

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In vivo drug delivery applications of nanogels: a review

Filippo Pinelli et al.

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Homopolymer self-assembly of poly(propylene sulfone) hydrogels via dynamic noncovalent sulfone-sulfone bonding

Fanfan Du et al.

NATURE COMMUNICATIONS (2020)

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Carbon Dot Cross-Linked Gelatin Nanocomposite Hydrogel for pH-Sensing and pH-Responsive Drug Delivery

Swarup Krishna Bhattacharyya et al.

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Self-Assembled Herbal Medicine Encapsulated by an Oxidation-Sensitive Supramolecular Hydrogel for Chronic Wound Treatment

Weiyi Zhao et al.

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Effect of Inhibiting Tumor Angiogenesis After Embolization in the Treatment of HCC with Apatinib-Loaded p(N-Isopropyl-Acrylamide-co-Butyl Methyl Acrylate) Temperature-Sensitive Nanogel

Chen Zhou et al.

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Mechano-Responsive, Tough, and Antibacterial Zwitterionic Hydrogels with Controllable Drug Release for Wound Healing Applications

Kun Fang et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Thermo- and pH-sensitive glycosaminoglycans derivatives obtained by controlled grafting of poly(N-isopropylacrylamide)

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Bottom-up assembly of nanocellulose structures

Elina Niinivaara et al.

CARBOHYDRATE POLYMERS (2020)

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The gamut of perspectives, challenges, and recent trends forin situhydrogels: a smart ophthalmic drug delivery vehicle

Beauty Das et al.

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Stimuli-responsive polymer/nanomaterial hybrids for sensing applications

Tong Shu et al.

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Local release of siRNA using polyplex-loaded thermosensitive hydrogels

Lies A. L. Ftiervoet et al.

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A review on recent advances in polymer and peptide hydrogels

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Multifunctional PVCL nanogels with redox-responsiveness enable enhanced MR imaging and ultrasound-promoted tumor chemotherapy

Fang Xu et al.

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Injectable thermosensitive hydrogel systems based on functional PEG/PCL block polymer for local drug delivery

Hongzhang Deng et al.

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Highly Dynamic Nanocomposite Hydrogels Self-Assembled by Metal Ion-Ligand Coordination

Kunyu Zhang et al.

SMALL (2019)

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Mechanics of controlled release of insulin entrapped in polyacrylic acid gels via variable electrical stimuli

Samavath Mallawarachchi et al.

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Magnetic Responsive PVA Hydrogels for Remote Modulation of Protein Sorption

Ana C. Manjua et al.

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Immobilized Transforming Growth Factor-Beta 1 in a Stiffness-Tunable Artificial Extracellular Matrix Enhances Mechanotransduction in the Epithelial Mesenchymal Transition of Hepatocellular Carcinoma

Rui-Zhi Tang et al.

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Self-Assembled Injectable Nanocomposite Hydrogels Coordinated by in Situ Generated CaP Nanoparticles for Bone Regeneration

Lijun Kuang et al.

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Light-Driven Shape Morphing, Assembly, and Motion of Nanocomposite Gel Surfers

Hyunki Kim et al.

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Tetra-PEG Based Hydrogel Sealants for In Vivo Visceral Hemostasis

Yazhong Bu et al.

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Thermosensitive hydrogels for sustained-release of sorafenib and selenium nanoparticles for localized synergistic chemoradiotherapy

Lan Zheng et al.

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An injectable thermosensitive photothermal-network hydrogel for near-infrared-triggered drug delivery and synergistic photothermal-chemotherapy

Chanjuan Liu et al.

ACTA BIOMATERIALIA (2019)

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Dual-functionalized hyaluronic acid as a facile modifier to prepare polyanionic collagen

Min Zhang et al.

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A Soft Matrix Enhances the Cancer Stem Cell Phenotype of HCC Cells

Boren Tian et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Recent Advances on Polymeric Beads or Hydrogels as Embolization Agents for Improved Transcatheter Arterial Chemoembolization (TACE)

Yun-Ping Chen et al.

FRONTIERS IN CHEMISTRY (2019)

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Injectable peptide hydrogel as intraperitoneal triptolide depot for the treatment of orthotopic hepatocellular carcinoma

Xiyue Zhao et al.

ACTA PHARMACEUTICA SINICA B (2019)

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Myocardial-Infarction-Responsive Smart Hydrogels Targeting Matrix Metalloproteinase for On-Demand Growth Factor Delivery

Caixia Fan et al.

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Recent Developments and Therapeutic Strategies against Hepatocellular Carcinoma

Mark Yarchoan et al.

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Strategies for Hyaluronic Acid-Based Hydrogel Design in Drug Delivery

Sonia Trombino et al.

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Microporous methacrylated glycol chitosan-montmorillonite nanocomposite hydrogel for bone tissue engineering

Zhong-Kai Cui et al.

NATURE COMMUNICATIONS (2019)

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Rebuilding Postinfarcted Cardiac Functions by Injecting TIIA@PDA Nanoparticle-Cross-linked ROS-Sensitive Hydrogels

Wei Wang et al.

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Soft Hyaluronic Gels Promote Cell Spreading, Stress Fibers, Focal Adhesion, and Membrane Tension by Phosphoinositide Signaling, Not Traction Force

Kalpana Mandal et al.

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Smart Hydrogels in Tissue Engineering and Regenerative Medicine

Somasundar Mantha et al.

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Photo-triggered polymer nanomedicines: From molecular mechanisms to therapeutic applications

Louis Beaute et al.

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Photodetachable Adhesion

Yang Gao et al.

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Redox/pH dual-stimuli responsive camptothecin prodrug nanogels for on-demand drug delivery

Ying Qu et al.

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Liver Cancer: Current and Future Trends Using Biomaterials

Sue Anne Chew et al.

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Co-assembled supramolecular hydrogels of cell adhesive peptide and alginate for rapid hemostasis and efficacious wound healing

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SOFT MATTER (2019)

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Physically crosslinked injectable hydrogels for long-term delivery of oncolytic adenoviruses for cancer treatment

Thai Minh Duy Le et al.

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Diffusion-limited dissolution of calcium carbonate in a hydrogel

Alexandre Turani-i-Belloto et al.

SOFT MATTER (2019)

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Stress relaxing hyaluronic acid-collagen hydrogels promote cell spreading, fiber remodeling, and focal adhesion formation in 3D cell culture

Junzhe Lou et al.

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Ionic liquid syntheses via click chemistry: expeditious routes toward versatile functional materials

Arsalan Mirjafari

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Controlled gene and drug release from a liposomal delivery platform triggered by X-ray radiation

Wei Deng et al.

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Self-healing and superstretchable conductors from hierarchical nanowire assemblies

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NATURE COMMUNICATIONS (2018)

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Black-Phosphorus-Incorporated Hydrogel as a Sprayable and Biodegradable Photothermal Platform for Postsurgical Treatment of Cancer

Jundong Shao et al.

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Hydrogel-Tissue Chemistry: Principles and Applications

Viviana Gradinaru et al.

ANNUAL REVIEW OF BIOPHYSICS, VOL 47 (2018)

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Therapeutic Effect of Sorafenib-Loaded TPGS-b-PCL Nanoparticles on Liver Cancer

Xiaolong Tang et al.

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Nanocomposite Hydrogels and Their Applications in Tissue Engineering

Andisheh Motealleh et al.

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Reactive-Oxygen-Species-Responsive Drug Delivery Systems: Promises and Challenges

Gurusamy Saravanakumar et al.

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Tracing the origins of relapse in acute myeloid leukaemia to stem cells

Liran I. Shlush et al.

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Water-Responsive Shape Recovery Induced Buckling in Biodegradable Photo-Cross-Linked Poly(ethylene glycol) (PEG) Hydrogel

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On-Demand Dissolution of Chemically Cross-Linked Hydrogels

Marlena D. Konieczynska et al.

ACCOUNTS OF CHEMICAL RESEARCH (2017)

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Enzymatically prepared redox-responsive hydrogels as potent matrices for hepatocellular carcinoma cell spheroid formation

Kousuke Moriyama et al.

BIOTECHNOLOGY JOURNAL (2016)

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Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems

Mahdi Karimi et al.

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Perivascular sustained release of atorvastatin from a hydrogel-microparticle delivery system decreases intimal hyperplasia

Ioanna Mylonaki et al.

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Enzymatically prepared redox-responsive hydrogels as potent matrices for hepatocellular carcinoma cell spheroid formation

Kousuke Moriyama et al.

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Magnetic Nanocomposite Hydrogel for Potential Cartilage Tissue Engineering: Synthesis, Characterization, and Cytocompatibility with Bone Marrow Derived Mesenchymal Stem Cells

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ACS APPLIED MATERIALS & INTERFACES (2015)

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Multistimuli-Responsive, Moldable Supramolecular Hydrogels Cross-Linked by Ultrafast Complexation of Metal Ions and Biopolymers

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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)

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Reactive Oxygen Species in Cancer: A Dance with the Devil

Paul T. Schumacker

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Stimuli-responsive PEGylated prodrugs for targeted doxorubicin delivery

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Reductively Responsive Hydrogel Nanoparticles with Uniform Size, Shape, and Tunable Composition for Systemic siRNA Delivery in Vivo

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PLGA: a unique polymer for drug delivery

Deepak N. Kapoor et al.

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Oxidation-responsive polymers for biomedical applications

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Injectable hyaluronic acid-tyramine hydrogels incorporating interferon-α2a for liver cancer therapy

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Mechanically Induced Gel Formation

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Development of in Situ Forming Thermosensitive Hydrogel for Radiotherapy Combined with Chemotherapy in a Mouse Model of Hepatocellular Carcinoma

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被撤回的出版物: Reactive oxygen species and tumor metastasis (Retracted article. See vol. 35, pg. 356, 2013)

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Current Progress in Reactive Oxygen Species (ROS)-Responsive Materials for Biomedical Applications

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Lipid-Based Nanovectors for Targeting of CD44-Overexpressing Tumor Cells

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Smart Self-Assembled Hybrid Hydrogel Biomaterials

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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2012)

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Galactose-Decorated pH-Responsive Nanogels for Hepatoma-Targeted Delivery of Oridonin

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Chitosan-g-poly(N-isopropylacrylamide) based nanogels for tumor extracellular targeting

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Structure and function of ALG-2, a penta-EF-hand calcium-dependent adaptor protein

Masatoshi Maki et al.

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Role of NADPH Oxidase in Endothelial Ischemia/Reperfusion Injury in Humans

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NOX Enzymes in the Central Nervous System: From Signaling to Disease

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Thermally triggered intracellular explosion of volume transition nanogels for necrotic cell death

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Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

Dunyaporn Trachootham et al.

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Effect of the physicochemical properties of poly(ethylene glycol) brushes on their binding to cells

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Oxidative and nitrative DNA damage as biomarker for carcinogenesis with special reference to inflammation

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ANTIOXIDANTS & REDOX SIGNALING (2006)

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ROS stress in cancer cells and therapeutic implications

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DRUG RESISTANCE UPDATES (2004)

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New gelatin-based hydrogels via enzymatic networking

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