Modularizable Liquid-Crystal-Based Open Surfaces Enable Programmable Chemical Transport and Feeding using Liquid Droplets

Droplet-based miniature reactors have attracted interest in both fundamental studies, for the unique reaction kinetics they enable, and applications in bio-diagnosis and material synthesis. However, the precise and automatic feeding of chemicals, important for the delicate reactions in these miniaturized chemical reactors, either requires complex, high-cost microfluidic devices or lacks the capability to maintain a pinning-free droplet movement. Here, the design and synthesis of a new class of liquid crystal (LC)-based open surfaces, which enable a controlled chemical release via a programmable LC phase transition without sacrificing the free transport of the droplets, are reported. It is demonstrated that their intrinsic slipperiness and self-healing properties enable a modularizable assembly of LC surfaces that can be loaded with different chemicals to achieve a wide range of chemical reactions carried out within the droplets, including sequential and parallel chemical reactions, crystal growth, and polymer synthesis. Finally, an LC-based chemical feeding device is developed that can automatically control the release of chemicals to direct the simultaneous differentiation of human induced pluripotent stem cells into endothelial progenitor cells and cardiomyocytes. Overall, these LC surfaces exhibit desirable levels of automation, responsiveness, and controllability for use in miniature droplet carriers and reactors.

Automated summary

Researchers have designed and synthesized a new class of open surfaces based on liquid crystal technology, which enable controlled chemical release through programmable liquid crystal phase transition without affecting droplet movement. These surfaces can be modularly assembled to achieve various chemical reactions within droplets, including sequential and parallel reactions, crystal growth, and polymer synthesis. In addition, a liquid crystal-based chemical feeding device has been developed to automatically control the release of chemicals for simultaneous cell differentiation.