4.5 Article

Symptomatic versus disease-modifying effects of psychiatric drugs

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

Antidepressants and health-related quality of life (HRQoL) for patients with depression: Analysis of the medical expenditure panel survey from the United States

Omar A. Almohammed et al.

Summary: Despite the empirical literature demonstrating the efficacy of antidepressant medications for treatment of depression disorder, the effect of these medications on patients' overall well-being and health-related quality of life remains controversial. This study found that while the use of antidepressant medications was associated with some improvement in the mental component summary, there was no significant difference in the physical component summary and mental component summary between patients who used antidepressants and those who did not.

PLOS ONE (2022)

Article Clinical Neurology

Esketamine Nasal Spray for Rapid Reduction of Depressive Symptoms in Patients With Major Depressive Disorder Who Have Active Suicide Ideation With Intent: Results of a Phase 3, Double-Blind, Randomized Study (ASPIRE II)

Dawn F. Ionescu et al.

Summary: This study confirmed rapid and robust reduction of depressive symptoms with esketamine nasal spray in severely ill patients with MDD who have active suicidal ideation with intent, showing significant improvements at 24 hours and earlier time points. Patients in both treatment groups experienced rapid reduction in suicidality scores, with no statistically significant difference between the groups. Common adverse events included dizziness, dissociation, nausea, dysgeusia, somnolence, headache, and paresthesia among esketamine-treated patients.

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2021)

Article Neurosciences

Antidepressant Paroxetine Exerts Developmental Neurotoxicity in an iPSC-Derived 3D Human Brain Model

Xiali Zhong et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2020)

Article Psychiatry

When and how to use lithium

S. A. Barroilhet et al.

ACTA PSYCHIATRICA SCANDINAVICA (2020)

Article Psychiatry

Glutamate in schizophrenia: Neurodevelopmental perspectives and drug development

Alice Egerton et al.

SCHIZOPHRENIA RESEARCH (2020)

Article Psychology, Multidisciplinary

The research evidence for schizophrenia as a neurodevelopmental disorder

Bjorn Rishovd Rund

SCANDINAVIAN JOURNAL OF PSYCHOLOGY (2018)

Review Psychiatry

The Long-Term Effects of Antipsychotic Medication on Clinical Course in Schizophrenia

Donald C. Goff et al.

AMERICAN JOURNAL OF PSYCHIATRY (2017)

Review Medicine, Research & Experimental

Maintenance efficacy designs in psychiatry: Randomized discontinuation trials - enriched but not better

S. N. Ghaemi et al.

JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE (2017)

Review Clinical Neurology

BDNF as a biomarker for successful treatment of mood disorders: A systematic & quantitative meta-analysis

Maryna Polyakova et al.

JOURNAL OF AFFECTIVE DISORDERS (2015)

Editorial Material Psychiatry

DSM-5 and the miracle that never happens

S. N. Ghaemi

ACTA PSYCHIATRICA SCANDINAVICA (2014)

Editorial Material Psychiatry

The 'pragmatic' secret of DSM revisions

S. Nassir Ghaemi

AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY (2014)

Article Ethics

Debating DSM-5: diagnosis and the sociology of critique

Martyn D. Pickersgill

JOURNAL OF MEDICAL ETHICS (2014)

Review Behavioral Sciences

Progressive brain changes in schizophrenia related to antipsychotic treatment? A meta-analysis of longitudinal MRI studies

P. Fusar-Poli et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2013)

Editorial Material Psychiatry

Taking disease seriously in DSM

S. Nassir Ghaemi

WORLD PSYCHIATRY (2013)

Review Medicine, General & Internal

Lithium in the prevention of suicide in mood disorders: updated systematic review and meta-analysis

Andrea Cipriani et al.

BMJ-BRITISH MEDICAL JOURNAL (2013)

Article Philosophy

THE DOPAMINE HYPOTHESIS OF SCHIZOPHRENIA: An Historical and Philosophical Analysis

Kenneth S. Kendler et al.

PHILOSOPHY PSYCHIATRY & PSYCHOLOGY (2011)

Review Biotechnology & Applied Microbiology

Alzheimer's disease: strategies for disease modification

Martin Citron

NATURE REVIEWS DRUG DISCOVERY (2010)

Article Biochemistry & Molecular Biology

How effective are second-generation antipsychotic drugs? A meta-analysis of placebo-controlled trials

S. Leucht et al.

MOLECULAR PSYCHIATRY (2009)

Article Medicine, General & Internal

Selective publication of antidepressant trials and its influence on apparent efficacy

Erick H. Turner et al.

NEW ENGLAND JOURNAL OF MEDICINE (2008)

Article Cardiac & Cardiovascular Systems

Blood pressure reduction and cardiovascular outcomes: past, present, and future

Giuseppe Mancia

AMERICAN JOURNAL OF CARDIOLOGY (2007)

Article Psychiatry

Suicidality in pediatric patients treated with antidepressant drugs

TA Hammad et al.

ARCHIVES OF GENERAL PSYCHIATRY (2006)

Article Medicine, General & Internal

Effectiveness of antipsychotic drugs in patients with chronic schizophrenia

JA Lieberman et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)